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Volume 9, Issue 29 (Summer 2015)
IJT 2015, 9(29): 1331-1335 |
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Zargari F, Ghorbanihaghjo A, Babaei H. Protective Effects of Hydroalcoholic Extract of Nasturtium officinale on Rat Blood Cells Exposed to Arsenic. IJT 2015; 9 (29) :1331-1335
URL: http://ijt.arakmu.ac.ir/article-1-392-en.html
URL: http://ijt.arakmu.ac.ir/article-1-392-en.html
1- Department of Medical Science ,Marand Branch ,Islamic Azad University , felorzargari@marandiau.ac.ir
2- Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Drug Applied Research Center, Tabriz, Iran
3- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Drug Applied Research Center, Tabriz, Iran
3- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: (4481 Views)
Background: Arsenic is one of the most toxic metalloids. Anemia and leukopenia are common results of poisoning with arsenic, which may happen due to a direct hemolytic or cytotoxic effect on blood cells. The aim of this study was to examine the effects of hydroalcoholic extract of Nasturtium officinale on blood cells and antioxidant enzymes in rats exposed to sodium (meta)arsenite.
Methods: 32 Male Sprague Dawley rats were randomly divided into four groups Group I (normal healthy rats), Group II (treated with 5.5mg/kg of body weight of NaAsO2), Group III (treated with 500mg/kg of body weight of hydro-alcoholic extract of N. officinale), and Group IV (treated with group II and III supplementations). Blood samples were collected and red blood cell, white blood cell, hematocrit, hemoglobin, platelet, total protein and albumin levels and total antioxidant capacity were measured. Data was analyzed with Mann-Whitney U test.
Results: WBC, RBC and Hct were decreased in the rats exposed to NaAsO2 (p<0.05). A significant increase was seen in RBC and Hct after treatment with the plant extract (p<0.05). There was no significant decrease in serum albumin and total protein in the groups exposed to NaAsO2 compared to the group I, but NaAsO2 decreased the total antioxidant capacity, significantly.
Conclusion: The Nasturtium officinale extract have protective effect on arsenic-induced damage of blood cells.
Methods: 32 Male Sprague Dawley rats were randomly divided into four groups Group I (normal healthy rats), Group II (treated with 5.5mg/kg of body weight of NaAsO2), Group III (treated with 500mg/kg of body weight of hydro-alcoholic extract of N. officinale), and Group IV (treated with group II and III supplementations). Blood samples were collected and red blood cell, white blood cell, hematocrit, hemoglobin, platelet, total protein and albumin levels and total antioxidant capacity were measured. Data was analyzed with Mann-Whitney U test.
Results: WBC, RBC and Hct were decreased in the rats exposed to NaAsO2 (p<0.05). A significant increase was seen in RBC and Hct after treatment with the plant extract (p<0.05). There was no significant decrease in serum albumin and total protein in the groups exposed to NaAsO2 compared to the group I, but NaAsO2 decreased the total antioxidant capacity, significantly.
Conclusion: The Nasturtium officinale extract have protective effect on arsenic-induced damage of blood cells.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
