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Volume 8, Issue 24 (Spring 2014)
IJT 2014, 8(24): 991-997 |
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Kalaiselvi A, Suganthy O M, Govindassamy P, Vasantharaja D, Gowri B, Ramalingam V. Influence of Aluminium Chloride on Antioxidant System in the Testis and Epididymis of Rats. IJT 2014; 8 (24) :991-997
URL: http://ijt.arakmu.ac.ir/article-1-292-en.html
URL: http://ijt.arakmu.ac.ir/article-1-292-en.html
Arumugam Kalaiselvi1 
, Onorine Marcelline Suganthy2 , Palaniandy Govindassamy2 , Dasal Vasantharaja1 , Balaji Gowri1 , Venugopal Ramalingam * 3
, Onorine Marcelline Suganthy2 , Palaniandy Govindassamy2 , Dasal Vasantharaja1 , Balaji Gowri1 , Venugopal Ramalingam * 3
1- Department of Zoology, K.M.Centre for Post Graduate Studies, Puducherry, India
2- Research and Development Centre, Bharathiar University, Coimbatore, India.
3- Department of Zoology, K.M.Centre for Post Graduate Studies, Puducherry, India , ramalingamv18@yahoo.com
2- Research and Development Centre, Bharathiar University, Coimbatore, India.
3- Department of Zoology, K.M.Centre for Post Graduate Studies, Puducherry, India , ramalingamv18@yahoo.com
Abstract: (11712 Views)
Background:In recent years, the use of chemicals in agriculture, industry, and public health has become so common that the environment is continuously contaminated by the toxic substance-like metals. Aluminum released due to anthropogenic activities such as mining and industrial uses. Aluminium has several industrial uses. The present study was designed to investigate the effect of aluminium chloride (AlCl3) on enzymatic and non-enzymatic antioxidants in the testis and epididymis of rats.
Methods:Adult male rats were administered with aluminium chloride at two different doses, 50 mg and 100 mg/kg body weight, orally, daily for 45 days. At the end of the experimental period, the animals were sacrificed and their testis and the epididymis were removed. Antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-s-transferase (GST) were assayed. Lipid peroxidation (LPO), vitamin C, and vitamin E levels were also determined.
Methods:Adult male rats were administered with aluminium chloride at two different doses, 50 mg and 100 mg/kg body weight, orally, daily for 45 days. At the end of the experimental period, the animals were sacrificed and their testis and the epididymis were removed. Antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-s-transferase (GST) were assayed. Lipid peroxidation (LPO), vitamin C, and vitamin E levels were also determined.
Results:Aluminium chloride administration had no effect on the bodyweight of the animals but the weight of the testis and epididymis was decreased. Almost all the antioxidant enzymes studied markedly diminished in the testis and epididymis of aluminium chloride treated animals. The non-enzymatic antioxidants, vitamin C and vitamin E, also declined. Lipid peroxidation, on the other hand, significantly increased. The influence was found to be more in 100 mg treated rats when compared to 50 mg treated rats.
Conclusions:The present study suggests the reproductive toxicity of aluminium by inducing the oxidative stress in the testis and epididymis and possible interference in sperm production and further maturational processes
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
