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:: Volume 11, Issue 3 (May-June 2017) ::
IJT 2017, 11(3): 47-50 Back to browse issues page
Effects of Vitamin C on Paraoxonase1 Arylesterase Activity in Rats Exposed to Arsenic
Felor Zargari , Hamid Tabaghchi Saeedy
Department of Medical Science, Marand Branch, Islamic Azad University, Marand, Iran. , zargarifkb@gmail.com
Abstract:   (1294 Views)

Background: Arsenic as an environmental toxicant is able to induced oxidative stress. The present study aimed to evaluate of vitamin C supplementation on the paraoxonase1 (PON1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic.

Methods: The study was conducted in the Faculty of Veterinary Medicine, Tabriz Islamic Azad University, Tabriz, Iran in 20015. Thirty-two adult male rats weighing 200-350 g were randomly divided into 4 groups: group I (Normal healthy rat), group II [treated with sodium arsenite (100 ppm in drinking water)], group III [treated with vitamin C supplementation (200 mg/kg via gavage)] group IV (treated with sodium arsenite and vitamin c 100 ppm and 200 mg/kg respectively).

Results: Vitamin C supplementation increased paraoxonase1 (PON1) arylesterase activity (P<0.05) but had no significant effect on serum levels of HDL, triglyceride and cholesterol.

Conclusion: PON1 arylesterase activity is independent of changes in HDL and lipid profile, and vitamin C with different mechanisms such as radical scavenging activity and reduction of oxidative stress leads to increased activity of paraoxonase.

Keywords: Arsenic, Paraoxonase 1, Rat, Vitamin C
Full-Text [PDF 200 kb]   (517 Downloads)    
Type of Study: Research | Subject: Special
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Zargari F, Tabaghchi Saeedy H. Effects of Vitamin C on Paraoxonase1 Arylesterase Activity in Rats Exposed to Arsenic. IJT. 2017; 11 (3) :47-50
URL: http://ijt.arakmu.ac.ir/article-1-546-en.html


Volume 11, Issue 3 (May-June 2017) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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