Volume 11, Issue 3 (May-June 2017)
IJT 2017, 11(3): 19-26 |
Back to browse issues page
1- Department of Animal Science Research, Yazd Agricultural and Natural Resources Research and Education Center, AREEO, Yazd, Iran.
2- Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran , hesarakisaeed@yahoo.com
3- Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran , hesarakisaeed@yahoo.com
3- Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract: (6064 Views)
Background: The aim of the present study was to find the effects of cadmium (Cd) on Japanese quail on the role of an animal model in order to understand the toxicity of Cd in creatures presented, within the environment.
Methods: One hundred 30-day-old male Japanese quails were equally divided into the control group and Cd group. The control group received no Cd while the Cd group was given formula feed comprised of 100 ppm of Cd (CdCl2, Merck, Germany) for sixty days. The histological and functional alteration in the liver and kidneys and the response of antioxidants were determined.
Results: Histological changes in the liver increased the number of kuppfer cells, vacuolar degeneration, and hepatocytes single cell necrosis in the Cd group. The renal histopathological changes were hyaline cast in renal tubules and necrosis and swelling of tubular epithelial cells. The level of aminotransferases (ALT and AST), blood urea nitrogen (BUN) and creatinine rose significantly in the Cd group toward the control group (P<0.05). The antioxidants (SOD, CAT and GSH) levels considerably diminished, while lipid peroxidation proliferated substantially in the hepatic and renal tissues of Japanese quails in the CD group (P<0.05).
Conclusion: Presentation to dietary Cd (100mg/kg diet) for 60 reduces the body weights gain and induces the histological and functional alteration in the liver and kidneys of Japanese quail as well as cellular antioxidant alterations.
References
1. LisunovaLI, Tokarev VS, Konstantinova NV. Physiological effect of cadmium on Japanese quail (Coturnix japonica). Russ Agr Sci 2008; 34(1):51-2. [DOI:10.3103/S1068367408010217]
2. Salinska A, Wlostowski T, Olenska E. Differential susceptibility to cadmium-induced liver and kidney injury in wild and laboratory-Bred bank voles Myodesglareolus. Archi Environ Contami Toxicol 2013; 65:324-31. [DOI:10.1007/s00244-013-9896-2]
3. Sant Ana MG, Moraes R, Bernardi MM. Toxicity of cadmium in Japanese quail: Evaluation of body weight, hepatic and renal function and cellular immune response. Environ Res 2003;99:273-7. [DOI:10.1016/j.envres.2005.06.003]
4. Pius J. Mechanisms of cadmium carcinogenesis. Toxicolo Appl Pharmacol 2009; 238:272-9. [DOI:10.1016/j.taap.2009.01.011]
5. SarkarA, Ravindran G, Krishnamurthy V. A brief review on the cadmium toxicity: from cellular to organ level. Int J BioTechn Res 2013; 3(1):17-36.
6. McFarland C, Bendell Young LI, Guglielmo C, Williams TD. Kidney, liver and bone cadmium content in the Western sandpiper in relation to migration. J Environ Monitor 2002; 4:791-5. [DOI:10.1039/b206045k]
7. Garcia Fernands AJ, Sanches Garcia JA, Gomes Zapata M, Luna A. Distribution of cadmium in blood and tissues of wild birds. Arch Environ ContamiToxicol 1996; 30:252-8. [DOI:10.1007/BF00215805]
8. Chlubek D, Grucka-Mamczar E, Birkner E, Polaniak R, Stawiarska-Pieta B, Duliban H. Activity of pancreatic antioxidative enzymes and malondialdehyde concentration in rats with hyperglycemia caused by fluoride intoxication. J Trace Elem MedBiol 2003;17(1):57-60. [DOI:10.1016/S0946-672X(03)80047-0]
9. Ognjanovic BI, Markoric SD, Pavolvic SZ, Zikic RV, Stajn AS, Saicic ZS. Effects of chronic cadmium exposure on antioxidant defense system in some tissue of rats: protective effect of selenium. Physiol Res 2008; 57:403-11.
10. Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicolo Appli Pharmacol 2009; 238:272-9. [DOI:10.1016/j.taap.2009.01.029]
11. Khandelwal S, Agnihotri N, TandonS K. Biochemical response to cadmium: dose-time effect. Biol Trace Elem Res 1991; 29: 157-64. [DOI:10.1007/BF03032693]
12. NovelliEI,Vierria EP, Rdrigues NL, Ribas BO. Risk assessment of cadmium toxicity on hepatic and renal tissue of rat. Environ Res 1998; 79(2):102-5. [DOI:10.1006/enrs.1998.3865]
13. Uyanik F, Eren M, AtaseverA,Tunoku G, Kolsuz AH. Changes in some biochemical parameters and organs of broiler exposed to cadmium and effects of zing on cadmium induced alteration. Israel J Vet Med 2001; 56(4):128-34.
14. Li JL, Li HZ, Li S, Tank ZX, Xu SW, Wang XL. Oxidative Stress-Mediated cytotoxicity of Cadmium in Chicken Splenic Lymphocytes. Pol J Environ Stud 2010; 19(5):947-756. [DOI:10.1016/j.toxlet.2010.03.429]
15. Cigankova V, Almasiova V, Holovska K. Morphological changes in duodenal epithelium of Japanese quail after chronic cadmium exposure. Pol J Environ Stud 2010;19(2):275-82.
16. Mihara M, Uchiyama M. Determination of malonaldehyde precursors in tissue by thiobarbituric acid test. Anal Biochem 1978; 86(1):271-8. [DOI:10.1016/0003-2697(78)90342-1]
17. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105:121-6. [DOI:10.1016/S0076-6879(84)05016-3]
18. Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972; 46:849-54. [DOI:10.1016/S0006-291X(72)80218-3]
19. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 61:882-8.
20. Teshfam M, Gharagozlu MJ, SalarAmoli J, Hassanpour H. Morphological alteration of the small intestine mucosa following oral administration of cadmium in broiler chicken. J Appl Anim Res 2006; 29 (1):65-8. [DOI:10.1080/09712119.2006.9706573]
21. Erdogan Z, Erdogan S, Celik S, Ulna A. Effects of ascorbic acid on cadmium-induced oxidative stress and performance of broilers. Biol Trace Elem Res 2005;104:19-32. [DOI:10.1385/BTER:104:1:019]
22. Li JL, Gao R, LiS, Wang JT, Tang ZX, Xu SW. Testicular toxicity induced by dietary cadmium in cooks and ameliorative effect by selenium. Biometals 2010; 23:695-705. [DOI:10.1007/s10534-010-9334-0]
23. Scheuhammer AM. The dose-dependent deposition of cadmium into organs of Japanese quail following oral administration.Toxicol Appl Pharmacol 1998; 95:153-61. [DOI:10.1016/S0041-008X(88)80014-0]
24. Bharavi K, Reddy AG, Rao G, Reddy AR, Rao SR. Reversal of cadmium-induced oxidative stress in chicken by herbal adaptogens Withania somnifera and Ocimum sanctum. Toxicol Int 2010;17(2):59. [DOI:10.4103/0971-6580.72671]
25. HolovskaK,Sobekova A, Almaslova V, Cigankova V. Morphological changes in the liver and the response of antioxidant enzymes after turkeys chronic exposure to cadmium. Pol J Environ Stud 2013;22(5):1371-9.
26. Karimi O, Hesaraki S, Mortazavi SP. Toxic effects of cadmium in Japanese quail (Coturnix japonica):Assessment of body weight and histopathology of liver and kidneys. Adv Environ Biol 2014; 8(17):288-94.
27. HesarakiS, Gharagozlou MJ, Salar Amoli J, Bokaee S, Javaheri Vaighan A. Histopathological and ultrastructural changes of kidneys in response to cadmium chloride toxicity in broiler chicken. J Vet Res 2008;65(4): 281-8.
28. Binkowski LJ, Sawicka Kapusta K, Szarek J, Stryzewska E, Felsmann M. Histopathology of liver and kidneys of wild living Mallards Anasplatyrhynchos and Coots Fulicaatra with considerable concentration of lead and cadmium. Sci Total Environ 2013; 450-451:326-33. [DOI:10.1016/j.scitotenv.2013.02.002]
29. Klaassen CD, LiuJ, Diwan BA. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 2009;238(3):215-28. [DOI:10.1016/j.taap.2009.03.026]
30. Kuester R K, Wagalkes M P, Goering P L, Fisher B L, McCuskey R, Spies I G. Differential hepatotoxicity induced by cadmium in Fischer 344 and Spargue-Duwley rats. Toxicol Sci 2002; 65:151-9. [DOI:10.1093/toxsci/65.1.151]
31. BrzoskaMM, Moniuszko Jakoniuk J, Pilat Marcinkiewicz B, Sawicki B. Liver andkidney function and histology in rats exposed to cadmium and ethanol. Alcohol Alcoholism 2003; 38(1):2-10 [DOI:10.1093/alcalc/agg006]
32. SwapanaG, Gopala Reddy A. Effect of cadmium on organ biomarkers and evaluation of certain adaptogens in broilers. Toxicol Int 2011;18(1):47-9. [DOI:10.4103/0971-6580.75856]
33. KamiyamaT, Miyakama H, Li JP, Akiba T, Liu JH,Liu J, Marumo F, Sato C. Effects of one year cadmium exposure on liver and kidneys and their relation to glutathione levels. Res Commun Mol Pathol Pharmacol 1995; 88:177-86.
34. Hagar H, Malki WA. Betaine supplementation protects against renalinjury induced by cadmium intoxication in rats: Role of oxidative stress and caspase-3. Environ Toxicolo Phar 2010; 37:803-11. [DOI:10.1016/j.etap.2014.02.013]
35. Fouad, AA, Jresat, IB. Protective effect of telmisartan against cadmium-induced nephrotoxicity in mice. Life Sci 2011; 89(1–2): 29–35. [DOI:10.1016/j.lfs.2011.04.019]
36. Shaikh ZA,Vu TT, Zamanak K. Oxidative stress as a mechanism of chronic cadmium induced hepathotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharma 1999; 154:256-63. [DOI:10.1006/taap.1998.8586]
37. Huang YH, Shih CM, Huang CJ, Lin C M, Chou CM, Tsai ML, LiuTP, Chiu JF, Chen CT. Effects of cadmium on structure and enzymatic activity of Cu, Zn-SOD andoxidative status in neural cells. J Cell Biochem 2006; 98 (3): 577–89. [DOI:10.1002/jcb.20772]
38. JihenEH, ImedM, Patina H, Kerkein A. Protective effects of selenium (se) and zing(zn) on cadmium(Cd) toxicity in the liver and kidneys of the rat : Effects on the oxidative stress. Ecotox Environ Saf 2008; 72: 1559-64. [DOI:10.1016/j.ecoenv.2008.12.006]
39. Wlostowski T, Dmowsk K, Bonda Ostaszewska E. Cadmium accumulation, metallthionein and glutathione levels and histopathological changes in the kidneys and liver of Magpie (Pica Pica) from a zing smelter area. Ecotoxicology 2010; 19:1066-73. [DOI:10.1007/s10646-010-0488-x]
40. Kant V, Mehata M,Varshneya C, Chauhan S. Induction of oxidative stress by subacute oral exposure of cadmium sulphate in adult poultry. BrazJ Vet Pathol 2011;4(2):117-21.
41. Karmakar R, Malay C. Cadmium-induced time dependent oxidative stress in liver of mice: a correlation with kidney. Environ Toxicol Phar 1998; 6:2012-07. [DOI:10.1016/S1382-6689(98)00035-0]
42. Casalino E, Calzaretti G, Sblano C, Landerisina C. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium.Toxicol 2002; 178(1-2):37-50. [DOI:10.1016/S0300-483X(02)00245-7]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |