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Volume 11, Issue 5 (September-October 2017)                   IJT 2017, 11(5): 5-11 | Back to browse issues page

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Heydari J, Jafari M, Khazaie S, Goosheh H, Ghanei M, Karbasi A. The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients. IJT 2017; 11 (5) :5-11
URL: http://ijt.arakmu.ac.ir/article-1-586-en.html
The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients
Javad Heydari1 , Mahvash Jafari * 2, Saeed Khazaie1 , Hassan Goosheh3 , Mostafa Ghanei3 , Ashraf Karbasi3
1- Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2- Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. , m.jafari145@gmail.com
3- MD, Pulmonologist, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Abstract:   (4449 Views)
Background: Sulfur mustard (SM) is a strong bifunctional alkylating agent that causes delayed complications in organs such as lung. Oxidative stress plays a pivotal role in the pathogenesis and progression of many pulmonary diseases. The aim of this study was to investigate the oxidative stress in sputum of SM exposed patients with mild, moderate and severe pulmonary dysfunction and assessing their relationship with pulmonary function.
Methods: In this cross–sectional study, oxidative stress biomarkers in sputum were examined on 26 patients with SM-induced bronchiolitis obliterans (9 mild, 14 moderate and 3 severe) and 12 matched healthy controls referred to Baqiyatallah Hospital, Tehran between October 2015 and April 2016.
Results: Sputum superoxide dismutase, catalase and glutathione S-transferase activities and malondialdehyde level in moderate and severe groups were significantly higher than in the control group (P=0.002, P=0.004, P=0.014 and P=0.009, respectively). Glutathione (GSH) level in moderate (22.29%, P=0.025) and severe (45.07%, P=0.004) groups were significantly lower than the control. A decreased in GSH level in severe (41.7%) groups was observed as compared with the mild group. Pearson analysis revealed strong correlations between disease severity and oxidative stress biomarkers in sputum of patients with moderate and severe injuries.
Conclusions: Oxidative stress is involved in the pathogenesis of patients with moderate and severe pulmonary dysfunction following SM exposure. The presence of enhanced oxidative stress relates to the decline lung function and the progression of the disease. Sputum induction in SM-injured patients can be used to the assessment of the antioxidant status of bronchial secretions.
Keywords: Oxidative Stress, Severity of Disease, Sputum, Sulfur Mustard
Full-Text [PDF 194 kb]   (1176 Downloads)    
Type of Study: Research | Subject: Special
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