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:: Volume 2, Issue 3 (Autumn 2009) ::
IJT 2009, 2(3): 221-227 Back to browse issues page
Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice
Kambiz Soltaninejad * , Shahin Shadnia , Fatemeh Hasaninejad , Friba Jabbari , Mohammad Abdollahi
Department of Forensic Toxicology, Legal Medicine Organization of Iran, Tehran, Iran , kamsoltani@yahoo.com
Abstract:   (5661 Views)
Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures in mice.
Material and methods: The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group.
Results: Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P<0.001).
Conclusion: Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice.
Keywords: Nimodipine, Ascorbic acid, Pentylenetetrazole, Seizures, Mice
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Type of Study: Research | Subject: General
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Soltaninejad K, Shadnia S, Hasaninejad F, Jabbari F, Abdollahi M. Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice. IJT. 2009; 2 (3) :221-227
URL: http://ijt.arakmu.ac.ir/article-1-72-en.html


Volume 2, Issue 3 (Autumn 2009) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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