Volume 2, Issue 3 (Autumn 2009)
IJT 2009, 2(3): 240-245 |
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1- Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
2- Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India , vivekdwivedi@venusremedies.com
2- Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India , vivekdwivedi@venusremedies.com
Abstract: (14215 Views)
Introduction: Nonsteroidal anti-inflammatory drugs are the most commonly used drugs to reduce pain and inflammation. Aceclofenac is a newer derivative of diclofenac with less gastrointestinal complications. The objective of the present study was to evaluate the toxicity profile of sustain release aceclofenac injection in rats at three dose levels, ranging from 2 to 10 mg/kg body weight.
Material & Methods: 48 Swiss albino rats were divided into four groups and were treated with saline or drug at three different doses for 28 days. Various physiological, hematological and biochemical parameters were studied.
Results: There were no mortality and signs of toxicity at different dose levels in any of the treatment groups. Hematological as well as biochemical parameters were unaffected at three different dose levels of aceclofenac sustain release injection.
Conclusion: These results indicated that aceclofenac injection is non-toxic even at higher dose level.
Material & Methods: 48 Swiss albino rats were divided into four groups and were treated with saline or drug at three different doses for 28 days. Various physiological, hematological and biochemical parameters were studied.
Results: There were no mortality and signs of toxicity at different dose levels in any of the treatment groups. Hematological as well as biochemical parameters were unaffected at three different dose levels of aceclofenac sustain release injection.
Conclusion: These results indicated that aceclofenac injection is non-toxic even at higher dose level.
Keywords: Aceclofenac, Delayed-Action Preparations, Acute Toxicity Test, Anti Inflammatory Agents, Non Steroidal, Hematological Tests, Biochemical Phenomena
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