Enter your email address
Submit
Write your message
Volume 14, Issue 3 (July 2020)
IJT 2020, 14(3): 179-186 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ilobekemen Ekakitie L, Ojo O A, Oyinloye B E, Olaitan Ajiboye B. Antioxidant and Inhibitory Activities of Enzymes Linked to Type II Diabetes Mellitus: The Novel Role of Chrysobalanus Orbicularis Leaf Extract. IJT 2020; 14 (3) :179-186
URL: http://ijt.arakmu.ac.ir/article-1-852-en.html
URL: http://ijt.arakmu.ac.ir/article-1-852-en.html
Lisa Ilobekemen Ekakitie1 
, Oluwafemi Adeleke Ojo * 
2, Babatunji Emmanuel Oyinloye3 , Basiru Olaitan Ajiboye1
, Oluwafemi Adeleke Ojo * 2, Babatunji Emmanuel Oyinloye3 , Basiru Olaitan Ajiboye1
1- Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
2- Department of Biochemistry, Landmark University, Omu-Aran, Kwara State, Nigeria. , sanaeizadeh@sums.ac.ir
3- Department of Biochemistry, Biochemical Toxicology and Biotechnology Research Laboratories, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria. Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, Kwa Dlangezwa 3886, South Africa.
2- Department of Biochemistry, Landmark University, Omu-Aran, Kwara State, Nigeria. , sanaeizadeh@sums.ac.ir
3- Department of Biochemistry, Biochemical Toxicology and Biotechnology Research Laboratories, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria. Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, Kwa Dlangezwa 3886, South Africa.
Abstract: (2147 Views)
Background: Chrysobalanus orbicularis is commonly used as food, the seeds as a spice for the popular pepper soup, and the leaves are traditionally utilized for managing Type II Diabetes Mellitus (T2DM) in the Niger Delta area of Nigeria. Due to the limited scientific evidence on C. orbicularis, this study investigated its antioxidant and inhibitory properties against major enzymes linked to T2DM.
Methods: The antioxidant activity was measured via methods for possible scavenging potentials. The α-amylase and α-glucosidase inhibitory activities were examined using a standard model.
Results: The C. orbicularis aqueous leaf extract compared well with the standard compounds, revealing the high antioxidant and inhibitory properties against α-amylase and α- glucosidase.
Conclusion: The findings validate the conventional application of C. orbicularis in the treatment of patients with type II diabetes mellitus and other oxidative stress-related disorders.
Methods: The antioxidant activity was measured via methods for possible scavenging potentials. The α-amylase and α-glucosidase inhibitory activities were examined using a standard model.
Results: The C. orbicularis aqueous leaf extract compared well with the standard compounds, revealing the high antioxidant and inhibitory properties against α-amylase and α- glucosidase.
Conclusion: The findings validate the conventional application of C. orbicularis in the treatment of patients with type II diabetes mellitus and other oxidative stress-related disorders.
Keywords: Antioxidant activity, C. orbicularis, α-amylase and α-glucosidase, Diabetes mellitus, Medicinal plants
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
