@ARTICLE{Allameh, author = {Hashemi, Seyed Ali and Allameh, Abdolamir ‎ and Daraei, Bahram and Moradi Peynevandi, Kamran and Pashazadeh‎, Ramin and }, title = {The Effect of Rebadioside A on Attenuation of Oxidative Stress in ‎Kidney of Mice under Acetaminophen Toxicity}, volume = {7}, number = {23}, abstract ={Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is ‎also believed that oxidative stress has a pivotal role in APAP-induced renal injury. ‎Therefore, protective effects of different antioxidants have been examined in APAP-‎induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. The aim of this study was to ‎investigate the possible protective effects of rebadioside A one of the main components ‎of stevia extract, on APAP-induced oxidative stress in kidney of mice. ‎ Methods: Oxidative stress was induced in kidney of BALB/c mice by the intraperitoneal ‎‎(i.p.) administration of a single dose of 300 mg/kg APAP. Some of these mice also ‎received rebadioside A (700 mg/kg) (i.p.) 30 minutes after APAP injection. Two and six ‎hours after APAP injection, all mice were sacrificed and malondialdehyde (MDA), ‎glutathione (GSH), free APAP, and glutathione conjugated of APAP (APAP-GSH) were ‎determined in the kidney tissue.‎ Results: GSH depletion and MDA levels significantly (P }, URL = {http://ijt.arakmu.ac.ir/article-1-270-en.html}, eprint = {http://ijt.arakmu.ac.ir/article-1-270-en.pdf}, journal = {Iranian Journal of Toxicology}, doi = {}, year = {2014} }