RT - Journal Article T1 - Attenuation of Biochemical, Haematological and Histological Indices of Alloxan Toxicity in Male Rats by Aqueous Extract of Fadogia agrestis (Schweinf. Ex Hiern) Stem JF - IJT YR - 2015 JO - IJT VO - 9 IS - 29 UR - http://ijt.arakmu.ac.ir/article-1-366-en.html SP - 1322 EP - 1330 K1 - Alloxan K1 - Diabetes Mellitus K1 - Fadogia agrestis K1 - Mitigation K1 - Reversal AB - Background: The effects of aqueous extract of Fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in Wistar rats. Methods: In total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (A-E): animals in group A received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in groups B, C, D and E also received orally 0.5 ml of distilled water and same volume of the extract corresponding to 18, 36, and 72 mg/kg body weight, respectively after which levels of some biomolecules were determined. Results: Administration of alloxan significantly (P LA eng UL http://ijt.arakmu.ac.ir/article-1-366-en.html M3 ER -