Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1391
4
1
gregorian
2012
7
1
6
17
online
1
fulltext
en
Methadone Detoxification versus Traditional Gradual Decrease in the Consumed Amount of Refined Opium Dross (Shireh): The Preferred Method for Controlling Withdrawal Syndrome
Methadone Detoxification versus Traditional Gradual Decrease in the Consumed Amount of Refined Opium Dross (Shireh): The Preferred Method for Controlling Withdrawal Syndrome
تخصصي
Special
پژوهشي
Research
<b>Background: </b>The aim of this study was to compare the effectiveness of methadone detoxification with traditional method of gradual decrement in the abused amount of the refined opium dross (Shireh) to control withdrawal syndrome in Shireh-addicted patients.
<b>Methods: </b>In this study, two groups of Shireh addicts were compared. The first group was treated by methadone and the second group by gradual decrement in the amount of consumed Shireh. Those experiencing the adverse effects of the treatment were excluded from the study.
Methadone dose was calculated based on the amount of the Shireh consumed and detoxification was performed during a 21-day period. In the second group, the amount of the consumed Shireh was gradually decreased within 21 days and some of the withdrawal symptoms were selected as indicators for patient evaluation.
<br><b>Results: </b>A total of 35 patients (16 versus 19 patients in the first and second groups) were evaluated. Their mean age was 43 ± 4 years and all were male. A statistically significant difference was found between these two groups in terms of severity and duration of withdrawal symptoms within the first five days and their duration after the 21st day of the onset of detoxification (P< 0.05).<br><b>Conclusion: </b>In comparison with methadone detoxification, traditional method of gradually decreasing the consumed amount of Shireh controls the severity and duration of withdrawal symptoms better in the course of detoxification.
Detoxification, methadone, refined opium dross, Shireh addict, withdrawal syndrome.
Detoxification, methadone, refined opium dross, Shireh addict, withdrawal syndrome.
638
641
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-94&slc_lang=en&sid=1
Mohammadreza
Farsinejad
محمدرضا
فارسی نژاد
10031947532846002908
10031947532846002908
No
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Hossein
Sanaei-Zadeh
حسین
صناعی زاده
h-sanaiezadeh@tums.ac.ir
10031947532846002909
10031947532846002909
Yes
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran