Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1391
4
1
gregorian
2012
7
1
6
17
online
1
fulltext
en
Toxicity of Margarine on liver Enzymes (Aspartate amino transferas and Alanine amino transferase) in Rats
Toxicity of Margarine on liver Enzymes (Aspartate amino transferas and Alanine amino transferase) in Rats
تخصصي
Special
پژوهشي
Research
<b>Background:</b> Margarine contain trans fatty acids as major sources of dietary free radicals, and oxidative stress. Effect of oral administration of margarine on hepatic enzyme was investigated in Wistar rats.
<br><b>Methods:</b> Thirty six (36) adult Wistar rats were uniformly divided into three groups of control , margarine 15% and 20%, twelve rats in each groups (6males & 6 females). Margarine was added to the second and third groups chow as 15% and 20% (w/w) respectively. After four months, their blood samples were obtained and the serum levels of Aspartate Amino Transferase (AST) and Alanine amino transferase (ALT) were measured. <br>
<b>Results: </b>Serum levels of AST and ALT in margarine groups were higher than control groups, but it was not significant. Treatment of rats with margarine were not significantly alter the serum levels of liver enzymes in all groups.
<br><b>Conclusion:</b> This result suggests that consumption of margarine may not be toxic at the doses investigated.
Alanine Aminotransferase, Margarine, Aspartate Aminotransferase.
Alanine Aminotransferase, Margarine, Aspartate Aminotransferase.
655
659
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-97&slc_lang=en&sid=1
Zahra
Salemi
زهرا
سالمی
dr.Zsalemi@arakmu.ac.ir
10031947532846002537
10031947532846002537
Yes
Assistant professor of biochemistry, Biochemistry Dep. Arak university of medical sciences, arak, Iran.
Assistant professor of biochemistry, Biochemistry Dep. Arak university of medical sciences, arak, Iran.
Samaneh
Kamali Pooya
سمانه
کمالی پویا
10031947532846002538
10031947532846002538
No
BSc. in Medical lab Science, Arak university of medical sciences, arak, Iran.
BSc. in Medical lab Science, Arak university of medical sciences, arak, Iran.