Iranian Journal of Toxicology

en Ameliorative Effect of Phyllanthus emblica Extract on Monosodium Glutamate-Induced Lipid Dyshomeostasis in Wistar Albino Rats تخصصي Special پژوهشي Research Background: Monosodium glutamate (MSG), a widely used food additive, has been linked to disruption of lipid homeostasis with prolonged exposure. Phyllanthus emblica, known for its antioxidant and lipid-regulating properties, was investigated in this study for its protective effects against MSG-induced lipid disturbances in Wistar albino rats. Methods: Adult Wistar albino rats were randomly assigned to seven groups with six animals in each group. The control group received distilled water. Three groups were treated with MSG at doses of 180 mg/kg, 360 mg/kg, and 720 mg/kg, respectively. Another three groups received the same MSG doses in combination with 75 mg/kg of an ethanolic extract of Phyllanthus emblica. All treatments were administered daily by oral gavage for 120 days. Upon completion of the experimental period, blood samples were collected for lipid profile analysis, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, and total cholesterol. Results: The MSG administration significantly increased LDL, triglycerides, and total cholesterol, while reducing HDL (P<0.05). Phyllanthus emblica extract improved these parameters in the low-dose MSG group (P<0.05); however, it failed to fully normalize lipid profiles at moderate and high MSG doses. Conclusion: Chronic MSG exposure disrupts lipid homeostasis, increasing LDL and triglycerides while reducing HDL. Phyllanthus emblica extract shows protective effects, especially at lower MSG doses, but its efficacy declines with higher exposure levels. Further studies are needed to elucidate the mechanisms and determine optimal dosing to restore lipid balance.   Dyslipidemia, Monosodium glutamate, Phyllanthus emblica, Triglycerides, Wistar albino rats 0 0 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-923-2&slc_lang=en&sid=1 Surendra Babu Thangachi surendra.07here@gmail.com 100319475328460019080 100319475328460019080 Yes Associate Professor, Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. Aga Ammar Murthuza ammar10861@gmail.com 100319475328460019081 100319475328460019081 No Professor, Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. Shabina komath chenoly shabina.chenoly@gmail.com 100319475328460019082 100319475328460019082 No Associate Professor, Department of Physiology, Faculty of Medicine, Vydehi Institute Of Medical Sciences And Research Centre, Bengaluru, Karnataka, India. Varsha Sriram Mokhasi vmokhasi@gmail.com 100319475328460019083 100319475328460019083 No Associate Professor, Department of Physiology, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. Shashi Rekha M dr.rekha_8@rediffmail.com 100319475328460019084 100319475328460019084 No Professor & HOD, Department of Anatomy, Faculty of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. Venkata Bharat Kumar Pinnelli pvbharatkumar@yahoo.co.in 100319475328460019085 100319475328460019085 No Professor & HOD, Department of Anatomy, Faculty of Medicine, Shri Gorakshnath Medical College Hospital and Research Centre, Gorakhpur, Uttar Pradesh, India.