Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1391
10
1
gregorian
2013
1
1
6
19
online
1
fulltext
en
Effect of Aluminium Phosphide Poisoning on Blood Cortisol Level
Effect of Aluminium Phosphide Poisoning on Blood Cortisol Level
عمومى
General
پژوهشي
Research
<b>Background: </b>Acute intoxication with ALP is extremely lethal. The present study was conducted to determine the range of serum cortisol levels in ALP poisoning and its correlation with patient outcome.
<br><b>Methods:</b> This study was carried out on patients who were intoxicated with ALP. Their demographic data and pertinent findings in their history and physical examination were recorded at the time of arrival and also when shock and severe metabolic acidosis emerged. 5cc blood was taken from the patients to measure blood cortisol level, when shock and severe metabolic acidosis developed. Blood cortisol level analysis was performed using ELISA method. Data analysis was done using SPSS software version 16.0.
<br><b>Results: </b>The average ingested dose was 1.98+1.79 tablets each containing 3 grams of ALP. Overall, 77% of the patients presented tachycardia and hypotension. Blood cortisol level less than 15 µg/dl, 15-33 µg/dl, and more than 34 µg/dl were regarded as adrenal insufficiency, critical illness-related corticosteroid insufficiency, and adequate adrenal response, respectively. Eventually, 3 patients fell within the first category, 24 patients matched with the second category, and 3 patients corresponded to the last category. <br>
<b>Conclusion</b>: Blood cortisol concentration is satisfactory only in 10% of the patients. In majority of the patients although it is not apparently low, it has not shown the expected rise comparable to the shock and stress state of such patients. It defines a role for corticosteroids therapy in management of ALP poisoning, particularly if it does not respond to conventional treatments.
Adrenal Insufficiency, Aluminum Phosphide, Cortisol, Poisoning, Shock.
Adrenal Insufficiency, Aluminum Phosphide, Cortisol, Poisoning, Shock.
746
750
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-29-14&slc_lang=en&sid=1
Fariba
Farnaghi
فریبا
فرنقی
10031947532846002418
10031947532846002418
No
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Haleh
Talaie
هاله
طالایی
10031947532846002419
10031947532846002419
No
Department of Infectious Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Infectious Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra
Pournasiri
زهرا
پورنصیری
10031947532846002420
10031947532846002420
No
Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Roksana
Sadeghi
رکسانا
صدقی
10031947532846002421
10031947532846002421
No
Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid
Owliaey
حمید
اولیایی
h_owliaey@yahoo.com
10031947532846002422
10031947532846002422
Yes
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein
Hassanian-Moghaddam
حسین
حسنیان مقدم
10031947532846002423
10031947532846002423
No
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahin
Shadnia
شاهین
شادنیا
10031947532846002424
10031947532846002424
No
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.