Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1393
3
1
gregorian
2014
6
1
8
25
online
1
fulltext
en
The Renal Protective Effects of Corn Silk and Feijoa by using in situ Rat Renal System
The Renal Protective Effects of Corn Silk and Feijoa by using in situ Rat Renal System
تخصصي
Special
پژوهشي
Research
<div align="left"><b>Background: </b>Corn silk (CS) is widely used in Iranian traditional medicine and Feijoa sellowiana(FS) is a native plant widespread in the Southern parts of Iran. The aim of the present study was to assess renal protective activities of CS and FS against dosage induced injury by ecstasy (MDMA) using insitu rat renal perfusion (IRRP) system.<br><b>Methods: </b>Hydro-alcoholic extract of CS and FS (10, 20, 40 and 100 mg/ kg) was studied for its renal protective activity by IRRP system. The kidneys were perfused with Kerbs-Henseleit buffer, containing different concentration of hydro-alcoholic (HA) extract of CS and FS (10, 20, 40, 50,100mg/kg) for 2 hours. During the perfusion, urea, creatinine and Glutathione (GSH) levels were assessed as indicators of renal viability. Consequently, sections of renal tissues were examined for any histopathological changes.
<br><b>Results: </b>The results showed that histopathological changes in renal tissue were related to HA extract of CS and FS concentrations in a dose-dependent manner. GSH levels in samples perfused by HA extract of CS and FS increased compared to the positive control group (P<0.05).<br> <b>Conclusion:</b> Renal protective effects of CS and FS are due to decreased lipid peroxidation, although other mechanisms may also be involved.
</div>
Acute Renal Injury,Corn Silk, Ecstasy (Mdma), Feijoa, Glutathione.
Acute Renal Injury,Corn Silk, Ecstasy (Mdma), Feijoa, Glutathione.
1060
1067
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-157&slc_lang=en&sid=1
Mohammad
Karami
محمد
کرمی
toxkarami@gmail.com.
10031947532846003510
10031947532846003510
Yes
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad
Shokerzadeh
محمد
شکرزاده
10031947532846003511
10031947532846003511
No
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Farshad
Naghshvar
فرشاد
نقشور
10031947532846003512
10031947532846003512
No
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari ,Iran.
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari ,Iran.
Shahram
Ala
شهرام
علا
10031947532846003513
10031947532846003513
No
Department of Clinical pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari ,Iran.
Department of Clinical pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari ,Iran.
Reza
Fezbakhsh
رضا
فیض بخش
10031947532846003514
10031947532846003514
No
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Anahita
Nosrati
آناهیتا
نصرتی
10031947532846003515
10031947532846003515
No
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari ,Iran.
Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari ,Iran.
Marjan
Makhloogh
مرجان
مخلوق
10031947532846003516
10031947532846003516
No
Institute of experimental animal research (IEAR), Mazandaran University of Medical Sciences, Sari, Iran.
Institute of experimental animal research (IEAR), Mazandaran University of Medical Sciences, Sari, Iran.