Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1394
11
1
gregorian
2016
2
1
10
2
online
1
fulltext
en
Clinical and Laboratory Findings of Lead Hepatotoxicity in the Workers of a Car Battery Manufacturing Factory
Clinical and Laboratory Findings of Lead Hepatotoxicity in the Workers of a Car Battery Manufacturing Factory
عمومى
General
پژوهشي
Research
<p style="text-align: left;"><strong>Background:</strong> Occupational lead poisoning is common in workers of some industries, but lead hepatotoxicity has rarely been reported. Several animal studies have revealed lead induced liver damage but clinical studies concerning the manifestations of lead induced liver toxicity in humans are scares. This study was designed to investigate the clinical manifestations and pathological parameters of hepatic dysfunction and its relationship with blood and urine lead concentrations in a car battery-manufacturing workers.</p>
<p style="text-align: left;"><strong>Methods:</strong> This cross sectional study was carried out in Mashhad, Iran, during April-June 2011. One hundred and twelve workers underwent blood and urine sampling for determination of lead concentrations and liver function tests. Clinical signs and symptoms of possible lead hepatotoxicity were investigated.</p>
<p style="text-align: left;"><strong>Results:</strong> Mean (±SD) age of the workers was 28.78 (±5.17) yr with a daytime work of 8.67 (±1.41) h and mean work duration of 3.89 (±2.40) yr. Mean blood lead concentration (BLC) and urine lead concentration (ULC) were 398.95 (±177.41) µg/l and 83.67(±50) μg/l, respectively. We found no correlation between the clinical findings and BLC or ULC. A weak correlation (R: 0.27, <em>P</em>=0.087) between serum alkaline phosphatase concentration and BLC was obtained. No significant relationship was found between other liver function tests and BLC or ULC.</p>
<p style="text-align: left;"><strong>Conclusion:</strong> We found no specific clinical and laboratory abnormalities of liver in the workers of car battery manufacturer who had chronic lead toxicity. Further investigations with more specific laboratory tests such as LDH5 and gamma glutamyl transferase (GGT) as well as novel biomarkers of metal induced hepatotoxicity might be helpful in evaluating lead hepatotoxicity.</p>
Lead Poisoning, Liver, Liver Function Tests, Occupational Exposure, Transaminases
1
6
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-327-1&slc_lang=en&sid=1
Bita
Dadpour
بیتا
دادپور
100319475328460011140
100319475328460011140
Yes
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza
Afshari
رضا
افشاری
100319475328460011141
100319475328460011141
No
Department of Addiction Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Addiction Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Reza
Mousavi
رسید رضا
موسوی
100319475328460011142
100319475328460011142
No
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sina
Kianoush
سینا
کیانوش
100319475328460011143
100319475328460011143
No
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohamad Reza
Keramati
محمدرضا
کرامتی
100319475328460011144
100319475328460011144
No
Department of Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Vali Allah
Moradi
ولی الله
مرادی
100319475328460011145
100319475328460011145
No
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahmood
Sadeghi
محمود
صادقی
100319475328460011146
100319475328460011146
No
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Faezeh
Madani Sani
فائزه
مدنی ثانی
100319475328460011147
100319475328460011147
No
Department of Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdi
Balali Mood
مهدی
بلالی مود
balalimoodM@mums.ac.ir
100319475328460011148
100319475328460011148
No
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.