Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1388
6
1
gregorian
2009
9
1
2
3
online
1
fulltext
en
Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat
Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat
عمومى
General
پژوهشي
Research
<span style="font-weight: bold">Introduction: </span>Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects. <br><span style="font-weight: bold">Material and Methods:</span> Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood. <br><span style="font-weight: bold">Results:</span> Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them. <br><span style="font-weight: bold">Conclusion:</span> Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage.
Malathion, Oxidative Stress, Pentoxifylline, Antioxidants Analysis, Rats
Malathion, Oxidative Stress, Pentoxifylline, Antioxidants Analysis, Rats
211
215
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-45&slc_lang=en&sid=1
Akram
Ranjbar
اکرم
رنجبر
a.rangbar@yahoo.com
10031947532846003335
10031947532846003335
Yes
Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran
Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran
Rezvan
Salehidoost
رضوان
صالحی دوست
10031947532846003336
10031947532846003336
No
Shariati Hospital Tehran University of Medical sciences, Tehran. Iran
Shariati Hospital Tehran University of Medical sciences, Tehran. Iran
Maryam
Baeeri
مریم
بعیری
10031947532846003337
10031947532846003337
No
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
Mohammad
Abdollahi
محمد
عبدالهی
10031947532846003338
10031947532846003338
No
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center