Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1397
4
1
gregorian
2018
7
1
12
4
online
1
fulltext
en
Evaluation of Cytotoxicity Effects of Combination Nano-Curcumin and Berberine in Breast Cancer Cell Line
عمومى
General
پژوهشي
Research
<strong>Background:</strong> Berberine and Nano-curcumin are two herbal medicines with strong anti-cancer effects on tumor cells, but low toxicity on normal cells, when used alone. Breast cancer is known as the most common cancer in women and second deadly one. In this study, we evaluated the cytotoxicity effects of combination Berberine and Nano-curcumin in breast cancer cell line to see whether they have further synergism cytotoxicity on MCF-7 breast cancer cell line.<br>
<strong>Methods:</strong> The cytotoxicity effects of Berberine and Nano-curcumin alone and in combination, were evaluated in MCF-7 cell lines using MTT cytotoxicity test. Statistical analysis is done through one-way ANOVA and Tukey multiple range tests.<br>
<strong>Results:</strong> Analyzing results of this study showed that cytotoxicity of Nano-curcumin was higher than Berberine in a dose-dependent manner. The IC50 of combination Berberine and Nano-curcumin was lower and showed higher cytotoxicity in MCF-7 cells compared with the time we use each of these drugs alone.<br>
<strong>Conclusion:</strong> In this study co-treatment of Berberine and Nano-curcumin significantly inhibited the growth of MCF-7 breast cancer cell line and resulted in synergism cytotoxicity effects. These results indicated on their potency to further combination of these two drugs with other agents and common chemotherapies to improve breast cancer outcomes.
Berberine, Breast Cancer, Nano Curcumin
47
50
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-546-1&slc_lang=en&sid=1
Parisa
ZiaSarabi
100319475328460011280
100319475328460011280
No
MSc of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
AmirReza
Hesari
100319475328460011281
100319475328460011281
No
Department of Biotechnology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Malihe
Bagheri
100319475328460011282
100319475328460011282
No
MSc of Medical Biotechnology, Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Maryam
Baazm
100319475328460011283
100319475328460011283
No
Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Faezeh
Ghasemi
ghasemi_f@arakmu.ac.ir
100319475328460011284
100319475328460011284
Yes
Department of Biotechnology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.