Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1388
6
1
gregorian
2009
9
1
2
3
online
1
fulltext
en
Sub Acute Toxicity of Aceclofenac Drug in Albino Rat
Sub Acute Toxicity of Aceclofenac Drug in Albino Rat
عمومى
General
پژوهشي
Research
<span style="font-weight: bold">Introduction:</span> Nonsteroidal anti-inflammatory drugs are the most commonly used drugs to reduce pain and inflammation. Aceclofenac is a newer derivative of diclofenac with less gastrointestinal complications. The objective of the present study was to evaluate the toxicity profile of sustain release aceclofenac injection in rats at three dose levels, ranging from 2 to 10 mg/kg body weight. <br><span style="font-weight: bold">Material & Methods:</span> 48 Swiss albino rats were divided into four groups and were treated with saline or drug at three different doses for 28 days. Various physiological, hematological and biochemical parameters were studied. <br><span style="font-weight: bold">Results:</span> There were no mortality and signs of toxicity at different dose levels in any of the treatment groups. Hematological as well as biochemical parameters were unaffected at three different dose levels of aceclofenac sustain release injection. <br><span style="font-weight: bold">Conclusion:</span> These results indicated that aceclofenac injection is non-toxic even at higher dose level.
Aceclofenac, Delayed-Action Preparations, Acute Toxicity Test, Anti Inflammatory Agents, Non Steroidal, Hematological Tests, Biochemical Phenomena
Aceclofenac, Delayed-Action Preparations, Acute Toxicity Test, Anti Inflammatory Agents, Non Steroidal, Hematological Tests, Biochemical Phenomena
240
245
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-50&slc_lang=en&sid=1
Anupama
Tamta
Anupama
Tamta
10031947532846003358
10031947532846003358
No
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Anurag
Payasi
Anurag
Payasi
10031947532846003359
10031947532846003359
No
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Manu
Chaudhary
Manu
Chaudhary
10031947532846003360
10031947532846003360
No
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Adnan
Ahmed
Adnan
Ahmed
10031947532846003361
10031947532846003361
No
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Vivek
Kumar Dwivedi
Vivek
Kumar Dwivedi
vivekdwivedi@venusremedies.com
10031947532846003362
10031947532846003362
Yes
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India
Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India