Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1398
10
1
gregorian
2020
1
1
14
1
online
1
fulltext
en
Child Death Due to Dermal Opium Application: A Case Report
عمومى
General
گزارش مورد
case report
<div style="text-align: justify;"><span style="color:#000080;"><strong>Background</strong></span>: Incorrect belief about opioid efficacy is a major cause of acute pediatric poisonings in Iran. We report a rare case of topical opium application that caused death in a 4-year-old child. <br>
<span style="color:#000080;"><strong>Case</strong></span>: A 4-year old girl was examined with burns over her abdominal area and lower extremities. Her parents had applied opium on burned area to relieve her pain. She was in delirium state and apnea without any evidence of infection. Immediately, she was administered a single dose of Naloxone (2mg). <br>
<span style="color:#000080;"><strong>Results</strong></span>: While blood oxygen saturation was improving, she aspirated her vomitus into the lungs and became hypotensive and pulseless. Her condition deteriorated and the treatment team’s efforts to resuscitate her failed. On her autopsy, there were no other abnormal findings, but codeine and morphine were detected in the autopsied tissue sample. <br>
<span style="color:#000080;"><strong>Conclusion</strong></span>: The plausible contributing factors may include: change in morphine pharmacokinetics in the burned skin; the low toxic dose of opium in children due to thin abdominal skin, and high blood perfusion in the burned areas.</div>
Dermal, opium, children, death, Iran, forensic toxicology
Dermal, Opium, Children death, Iran, Forensic toxicology
59
62
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-303-2&slc_lang=en&sid=1
Mohammad
Moshiri
محمد
مشیری
Moshirim@mums.ac.ir
100319475328460010587
100319475328460010587
No
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Arya
Hedjazi
آریا
حجازی
Aryahedjazi@gmail.com
100319475328460010588
100319475328460010588
No
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
Seyed Mohsen
Rezazadeh-Shojaie
سید محسن
زضا زاده شجاعی
Reazazadehsmm@yahoo.com
100319475328460010589
100319475328460010589
No
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
Leila
Etemad
لیلا
اعتماد
etemadl@mums.ac.ir
100319475328460010590
100319475328460010590
Yes
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
مرکز تحقیقات عوم دارویی