Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1399
4
1
gregorian
2020
7
1
14
3
online
1
fulltext
en
The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats
تخصصي
Special
پژوهشي
Research
<div style="text-align: justify;"><strong>Background</strong>: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats.<br>
<strong>Methods</strong>: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples.<br>
<strong>Results</strong>: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. <br>
<strong>Conclusion</strong>: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property.</div>
Indomethacin, Cold-shock response, Nortriptyline, Stomach, Oxidative stress
155
164
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-649-1&slc_lang=en&sid=1
Mohammad Javad
Khoshnoud
khoshnoudm@sums.ac.ir
10031947532846009608
10031947532846009608
No
Food and Supplements Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Majid
Keshavarzi
keshavarzi_majid@yahoo.com
10031947532846009609
10031947532846009609
No
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences. Shiraz, Iran.
Neda
Mokhtari
nedamokhtaripharmacy88@gmail.com
10031947532846009610
10031947532846009610
No
Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Amirhossein
Sakhteman
asakhteman@sums.ac.ir
10031947532846009611
10031947532846009611
No
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Amin
Derakhshanfar
derakhshanfar@sums.ac.ir
10031947532846009612
10031947532846009612
No
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Marzieh
Rashedinia
rashedinia@sums.ac.ir
10031947532846009613
10031947532846009613
Yes
Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.