Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1386
6
1
gregorian
2007
9
1
1
3
online
1
fulltext
en
Free Radical Scavenging Activity of Silymarin with Refrence to Depleted Uranium Induced Mitochondrial Dysfunction
Free Radical Scavenging Activity of Silymarin with Refrence to Depleted Uranium Induced Mitochondrial Dysfunction
عمومى
General
پژوهشي
Research
<span style="font-weight: bold">Introduction:</span> Recently depleted uranium is being widely used as anti-armour ammunition and at very high temperature, results in information of an aerosol of very small uranium oxide particles, which may be inhaled. It is alleged that these particles represent a new battlefield hazard because of the chemical toxicology and/or radioactivity.
<br><span style="font-weight: bold">Method & materials: </span>Male Wistar strain albino rats were divided at random into 3 groups. In the first group normal saline was administrated intraperitioneally (i.p) , this group served as controls. The second group were i.p injected with uranyl acetate 40 mg/kg. In the third group the rats received 100 mg/kg/day silymarin by i.p injection for 5 days and 1hr after the last injection animals were injected with a single i.p dose of uranyl acetate (40 mg/kg). Silymarin was tested for its free radical scavenging activity and protective role against mitochondrial dysfunction in uranyl acetate stressed rats.
<br><span style="font-weight: bold">Results:</span> Lipid peroxidation activity was increased and activity of mitochondrial enzymes (cytochrome-coxidases, NADH-dehydrogenase, α-ketoglutarate dehydrogenase and succinate dehydrogenase) and glutathione was decreased in the liver and kidney of rats intoxicated with uranyl acetate when compared to control rats. In traperitoneal administration of silymarin significantly reduced the lipid peroxidation, increased the activity of mitochondrial enzymes and increased glutathione to near control level.
<br><span style="font-weight: bold">Conclusion:</span> These results suggest that the major components in silymarin (including silybin A and B, isosilybin A and B, cis-silybin A and B) play a protective role through their free redical scavenging properties.
Silymarin, Depleted Uranium, Oxidative Stress, Mitochondrial Enzymes
Silymarin, Depleted Uranium, Oxidative Stress, Mitochondrial Enzymes
6
6
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-64&slc_lang=en&sid=1
Jalal
Pourahmad
جلال
پور احمد
j.pourahmadjaktaji@utoronto.ca
10031947532846003469
10031947532846003469
Yes
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran
Farahnaz
Tanbakosazan
فرحناز
تنباکوسازان
10031947532846003470
10031947532846003470
No
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran
Monireh
Ghashang
منیره
قشنگ
10031947532846003471
10031947532846003471
No
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran
Faculty of Pharmacy and Pharmaceutical Research Center, Shahid Beheshti Medical University, Tehran, Iran