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Volume 17, Issue 1 (January 2023)
IJT 2023, 17(1): 45-52 |
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Zoofaghari S J, Dorooshi G, Meamar R, Otroshi A, Gheshlaghi F, Mansourian M et al . Investigating the Efficacy of Sucralfate in the Treatment of Oral Paraquat Poisoning: A Randomized Double-Blind Clinical Trial. IJT 2023; 17 (1) :45-52
URL: http://ijt.arakmu.ac.ir/article-1-1162-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1162-en.html
Shafea Jafar Zoofaghari * 
1, Gholamali Dorooshi2 , Rokhsareh Meamar2 , Arman Otroshi2 , Farzad Gheshlaghi2 , Marjan Mansourian3 , Nastaran Izadi-mood4
1, Gholamali Dorooshi2 , Rokhsareh Meamar2 , Arman Otroshi2 , Farzad Gheshlaghi2 , Marjan Mansourian3 , Nastaran Izadi-mood4
1- Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran , shafeajafarzoofaghari@yahoo.com
2- Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3- Department of Epidemiology and Biostatistics, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4- Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3- Department of Epidemiology and Biostatistics, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4- Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract: (864 Views)
Background: There is a high prevalence of intentional paraquat poisoning especially for suicide reported from many part of the world, with its negative effects on the lungs, kidneys, heart, and digestive system. This study was planned, aimed at investigating the efficacy of sucralfate in the treatment of oral paraquat poisoning with respect to its clinical outcomes.
Methods: A randomized double-blind clinical trial was conducted on 70 patients, suffering from oral paraquat poisoning. These patients were divided into two groups of 35 each. Subsequently, gastric lavage was performed for each patient in the control and treatment groups with 5g sucralfate mixed in tap water in the treatment group, but with tap water alone in the controls. The patients’ hemodynamic and laboratory parameters were evaluated and recorded, on admission and the hospital discharge dates. In addition, the patients’ final clinical outcome, including survival or death was also recorded.
Results: The results of the present study revealed that the patients’ hemodynamic parameters, coagulation factors, renal and liver laboratory findings did not differ significantly between the two groups (P>0.05). Moreover, 45.7% and 31.4% of the patients died in the control and treatment groups, respectively (P>0.05).
Conclusions: The sucralfate administration did not have a significant effect on the patients’ hemodynamic and laboratory parameters. The survival of patients in the treatment group was slightly higher than those in the control group. Also the patients in the treatment group had less pulmonary and renal complications in the long-term than those in the control group.
Methods: A randomized double-blind clinical trial was conducted on 70 patients, suffering from oral paraquat poisoning. These patients were divided into two groups of 35 each. Subsequently, gastric lavage was performed for each patient in the control and treatment groups with 5g sucralfate mixed in tap water in the treatment group, but with tap water alone in the controls. The patients’ hemodynamic and laboratory parameters were evaluated and recorded, on admission and the hospital discharge dates. In addition, the patients’ final clinical outcome, including survival or death was also recorded.
Results: The results of the present study revealed that the patients’ hemodynamic parameters, coagulation factors, renal and liver laboratory findings did not differ significantly between the two groups (P>0.05). Moreover, 45.7% and 31.4% of the patients died in the control and treatment groups, respectively (P>0.05).
Conclusions: The sucralfate administration did not have a significant effect on the patients’ hemodynamic and laboratory parameters. The survival of patients in the treatment group was slightly higher than those in the control group. Also the patients in the treatment group had less pulmonary and renal complications in the long-term than those in the control group.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
