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Volume 12, Issue 3 (May-June 2018)
IJT 2018, 12(3): 21-27 |
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Kenfack A, Akono Nantia E, Ngoula F, Guiekep Nounamo A J, Kamtchouing P, Tchoumboue J. Post Exposure Effects of Propoxur (Agricultural Pesticide) on Male Fertility in Wistar Rat. IJT 2018; 12 (3) :21-27
URL: http://ijt.arakmu.ac.ir/article-1-660-en.html
URL: http://ijt.arakmu.ac.ir/article-1-660-en.html
Augustave Kenfack1 
, Edouard Akono Nantia * 2, Ferdinand Ngoula1 , Arthénice Jemima Guiekep Nounamo1 , Pierre Kamtchouing3 , Joseph Tchoumboue1
, Edouard Akono Nantia * 2, Ferdinand Ngoula1 , Arthénice Jemima Guiekep Nounamo1 , Pierre Kamtchouing3 , Joseph Tchoumboue1
1- Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon.
2- Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon. , akonoed@yahoo.fr
3- Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
2- Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon. , akonoed@yahoo.fr
3- Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Abstract: (3771 Views)
Background: Pesticide toxicity is one of the major environmental health problems for the modern societies, as some of the effects may last long time after exposure. Propoxur is one of the Carbamate pesticide largely used in agriculture in the Western region of Cameroon.
Methods: In order to evaluate the post-exposure effects of propoxur, 48 male rats (12 animals per group) aged 30 d were orally gavaged with 0.00, 1.73, 2.60 and 5.20 mg.kg-1 body weight of propoxur for 90 d. At the end of treatment, 6 rats per group were sacrificed and others were followed up for 90 additional days and submitted to a fertility test before sacrifice.
Results: At the end of exposure propoxur significantly increased (P<0.05) the testis weight while it decreased (P<0.05) the cauda epididymal sperm motility in rat. Propoxur treatment and post-treatment exposure showed variable effect on the fertility rate with an increase and decrease at 2.60 and 5.20 mg.kg-1, respectively. At the 90th day post treatment, there was a significant decrease (P<0.05) in epididymis weight and sperm count and motility (P<0.05). In addition, post-exposure treatment with propoxur reduced (P<0.05) the pup litter size and the sex ratio at all doses. Histopathological examination revealed a high vacuity of germinal epithelia in treated rats that persisted after post-exposure time.
Conclusion: Propoxur negatively affected male rats’ reproductive parameters with more significant adverse effects observed 90 d after the end of exposure.
Methods: In order to evaluate the post-exposure effects of propoxur, 48 male rats (12 animals per group) aged 30 d were orally gavaged with 0.00, 1.73, 2.60 and 5.20 mg.kg-1 body weight of propoxur for 90 d. At the end of treatment, 6 rats per group were sacrificed and others were followed up for 90 additional days and submitted to a fertility test before sacrifice.
Results: At the end of exposure propoxur significantly increased (P<0.05) the testis weight while it decreased (P<0.05) the cauda epididymal sperm motility in rat. Propoxur treatment and post-treatment exposure showed variable effect on the fertility rate with an increase and decrease at 2.60 and 5.20 mg.kg-1, respectively. At the 90th day post treatment, there was a significant decrease (P<0.05) in epididymis weight and sperm count and motility (P<0.05). In addition, post-exposure treatment with propoxur reduced (P<0.05) the pup litter size and the sex ratio at all doses. Histopathological examination revealed a high vacuity of germinal epithelia in treated rats that persisted after post-exposure time.
Conclusion: Propoxur negatively affected male rats’ reproductive parameters with more significant adverse effects observed 90 d after the end of exposure.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
