@ARTICLE{Ranjbar, author = {Ranjbar, Akram and Salehidoost, Rezvan and Baeeri, Maryam and Abdollahi, Mohammad and }, title = {Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat}, volume = {2}, number = {3}, abstract ={Introduction: Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects. Material and Methods: Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood. Results: Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them. Conclusion: Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage. }, URL = {http://ijt.arakmu.ac.ir/article-1-70-en.html}, eprint = {http://ijt.arakmu.ac.ir/article-1-70-en.pdf}, journal = {Iranian Journal of Toxicology}, doi = {}, year = {2009} }