Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1401
10
1
gregorian
2023
1
1
17
1
online
1
fulltext
en
Investigating the Efficacy of Sucralfate in the Treatment of Oral Paraquat Poisoning: A Randomized Double-Blind Clinical Trial
عمومى
General
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> There is a high prevalence of intentional paraquat poisoning especially for suicide reported from many part of the world, with its negative effects on the lungs, kidneys, heart, and digestive system. This study was planned, aimed at investigating the efficacy of sucralfate in the treatment of oral paraquat poisoning with respect to its clinical outcomes.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> A randomized double-blind clinical trial was conducted on 70 patients, suffering from oral paraquat poisoning. These patients were divided into two groups of 35 each. Subsequently, gastric lavage was performed for each patient in the control and treatment groups with 5g sucralfate mixed in </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">tap water in the treatment group, but with tap water alone in the controls. The patients’ hemodynamic and laboratory parameters were evaluated and recorded, on admission and the hospital discharge dates. In addition, the patients’ final clinical outcome, including survival or death was also recorded.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The results of the present study revealed that the patients’ hemodynamic parameters, coagulation factors, renal and liver laboratory findings did not differ significantly between the two groups (<i>P</i>>0.05). Moreover, 45.7% and 31.4% of the patients died in the control and treatment groups, respectively (<i>P</i>>0.05). </span></span></span></span></span><br>
<b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusions:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> The sucralfate administration did not have a significant effect on the patients’ hemodynamic and laboratory parameters. The survival of patients in the treatment group was slightly higher than those in the control group. Also the patients in the treatment group had less pulmonary and renal complications in the long-term than those in the control group. </span></span></span><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> </span></span></span></span></span></span></span></div>
Critical care outcomes, Paraquat, Poisoning, Sucralfate, Suicide
45
52
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1025-1&slc_lang=en&sid=1
Shafea Jafar
Zoofaghari
shafeajafarzoofaghari@yahoo.com
100319475328460014492
100319475328460014492
Yes
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Gholamali
Dorooshi
gdorvashy@med.mui.ac.ir
100319475328460014493
100319475328460014493
No
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Rokhsareh
Meamar
rokhsarehmeamar@gmail.com
100319475328460014494
100319475328460014494
No
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Arman
Otroshi
arman_otroshi@yahoo.com
100319475328460014495
100319475328460014495
No
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Farzad
Gheshlaghi
gheshlaghi@med.mui.ac.ir
100319475328460014496
100319475328460014496
No
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Marjan
Mansourian
jmansourian@gmail.com
100319475328460014497
100319475328460014497
No
Department of Epidemiology and Biostatistics, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Nastaran
Izadi-mood
izadi@med.mui.ac.ir
100319475328460014498
100319475328460014498
No
Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.