Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1391
4
1
gregorian
2012
7
1
6
17
online
1
fulltext
en
Cerebrospinal Fluid Indices in Acute Drug Intoxication Do they Predict the Patients’ Outcome?
Cerebrospinal Fluid Indices in Acute Drug Intoxication Do they Predict the Patients’ Outcome?
تخصصي
Special
پژوهشي
Research
<b> Introduction:</b> In some intoxicated patients, cerebrospinal fluid (CSF) is examined due to the prolonged loss of consciousness, focal neurologic findings, and fever of unknown origin. We aimed to evaluate the probable relationship between the different toxicity causes and the CSF indices in poisoned patients and determine if they could predict the patients’ outcome. <br><b>Methods:</b> All patients who had been admitted to the toxicology intensive care unit of Loghman-Hakim hospital between March 2006 and March 2011 and had undergone lumbar puncture (LP) were included into this retrospective study. The patients’ demographic data and results of CSF evaluation (level of glucose, lactate dehydrogenase, protein, and white blood cells in CSF fluid) were evaluated. The data was analyzed using SPSS software version 17.<br><b>Results: </b>A total of 111 patients were evaluated. Mean age of the patients was 37±15 years. Thirteen (11.7%) had deceased. No relation was found between the cause of poisoning (medication involved) and the changes in CSF indices. A statistically significant difference was found between the survivors and non-survivors in terms of CSF protein, LDH, and WBC. However, such a difference was not detected between these two groups regarding CSF glucose. <br><b>Conclusion: </b>In intoxicated patients with prolonged decreased level of consciousness or prolonged fever, early evaluation of CSF can help early diagnosis of complications such as meningitis and prompt treatment. Also, high level of protein, LDH, and WBC in the CSF can predict higher mortality rates in these patients.
Poisoning, Toxicity, Cerebrospinal Fluid, Lumbar Puncture, White Blood Cell, Lactate Dehydrogenase.
Poisoning, Toxicity, Cerebrospinal Fluid, Lumbar Puncture, White Blood Cell, Lactate Dehydrogenase.
635
637
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-93&slc_lang=en&sid=1
Mohammadreza
Farsinejad
محمدرضا
فارسی نژاد
10031947532846002910
10031947532846002910
No
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Nahid
Kazemzadeh
ناهید
کاظم زاده
10031947532846002911
10031947532846002911
No
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Mohammadali
Emamhadi
محمدعلی
امام هادی
10031947532846002912
10031947532846002912
No
Department of Forensic Medicine and Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nasim
Zamani
نسیم
زمانی
10031947532846002913
10031947532846002913
No
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Hossein
Sanaei-Zadeh
حسین
صناعی زاده
h-sanaiezadeh@tums.ac.ir
10031947532846002914
10031947532846002914
Yes
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran