en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span new="" roman="" style="font-family:" times=""><b>Background: </b>Beryllium (Be) is an element used in various industries, such as nuclear and microelectronic industries. Be release into the environment raises its toxic effects and increases the likelihood of exposure to humans, which causes many hazardous side effects, such as cancer and skin allergic conditions. </span><br> <span new="" roman="" style="font-family:" times=""><b>Methods: </b>This study investigated the role of tannic acid (TA) in counteracting the hazardous effects and the accumulation of Be. We made daily injections intraperitoneally into 72 adult male albino rats for 14 days. Animals were divided into four groups: control, Be, TA, and Be+TA. The animals were sacrificed at 1, 7, or 14 days into the study. </span><br> <span new="" roman="" style="font-family:" times=""><b>Results: </b>The data provided evidence that Be accumulations were found in different body organs, which were ranked as follows: lung>liver>kidneys>brain>testes. Be accumulations lowered the rats&rsquo; blood glucose levels significantly. In addition, the liver function tests showed significant increases in bilirubin and transaminase enzymes in the animals. We also found significant declines in alkaline phosphatase, albumin, and proteins in these animals. Further, significant rises occurred in the kidneys&rsquo; secretions of creatinine, urea, uric acid, lipids, cholesterol, and triglycerides. The TA administration ameliorated the toxic effects of Be on all of the tested variables. The rise in malondialdehyde and the decline in glutathione levels in the kidneys and liver improved after the TA treatment. </span></span><br> <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:12px;"><b><span style="letter-spacing:-.1pt">Conclusion: </span></b></span><span style="font-size:8.0pt"><span style="font-size:12px;">The findings of this study provided evidence that TA administration effectively counteracted the toxic effects of Be administration in rats.</span> </span></span></span></div> Antioxidants, Beryllium, Kidneys, Liver, Physiological hazards, Tannic acid 84 92 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1184-1&slc_lang=en&sid=1 Mohamed M. Rezk Mohamed M. Rezk ddrezk@yahoo.com 100319475328460016599 100319475328460016599 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Tarek F Mohammedan tfm20008@hotmail.com 100319475328460016600 100319475328460016600 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Wesam M Morsi mahmoud2_nma @yahoo.com 100319475328460016601 100319475328460016601 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Walaa S. Hafez walaasaeed12_h@yahoo.com 100319475328460016602 100319475328460016602 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Mohamed F. Cheira mf.farid2008@yahoo.com 100319475328460016603 100319475328460016603 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Sameh H. Negm samehnegm.nma@gmail.com 100319475328460016604 100319475328460016604 No Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt Mahmoud O. Abd El-Magied mahmoud_nma@yahoo.com 100319475328460016605 100319475328460016605 Yes Isotope Geology Department, Nuclear Materials Authority, Cairo, Egypt