en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span new="" roman="" style="font-family:" times=""><b>Background: </b>Nowadays, therapeutic plasma exchange (TPE) is considered a novel and promising treatment in cases of poisoning. However, few studies have been conducted on the use of TPE as a treatment in various toxicity cases, especially aluminum phosphide (AlP) poisoning. Therefore, the present study aimed to investigate the efficacy of plasmapheresis in the treatment and clinical outcome of patients with AlP poisoning.</span><br> <span new="" roman="" style="font-family:" times=""><b>Methods: </b>We conducted this randomized controlled clinical trial on 80 patients poisoned with AlP. The control patients (n=58) received only the routine treatment, whereas those in the experimental group (n=22) underwent plasmapheresis in addition to the routine treatment. The plasmapheresis was given to these patients immediately after they had received the routine treatment, within the first six hours of their hospital admission.</span><br> <span new="" roman="" style="font-family:" times=""><b>Results: </b>The study results revealed that the mean hematocrit level in the plasmapheresis group (34.31&plusmn;3.31%) was significantly lower than that of patients in the control group (38.05&plusmn;4.80%) 12 h after the plasmapheresis treatment (P=0.046). Moreover, there were six (27.3%) and 14 (24.1%) cases of mortality in the plasmapheresis group and the control group, respectively. There was no significant difference in the mortality rates between the two groups (P=0.778).</span><br> <span new="" roman="" style="font-family:" times=""><b><span style="letter-spacing:-.1pt">Conclusion: </span></b>Based on the results of this study, plasmapheresis had a significant effect on increasing the blood HCO₃ level within 12 h after the intervention. Therefore, it had a significant role in reducing the resultant acidosis in patients with AlP poisoning; however, this effect did not reduce the mortality rate after plasmapheresis. </span></span></div> Aluminum phosphide, Complication, Mortality, Plasmapheresis, Poisoning 113 119 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1025-2&slc_lang=en&sid=1 Shiva Samsaam Shariat samsamshariat@Omed.mui.ac.ir 100319475328460016616 100319475328460016616 No Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Farzad Gheshlaghi gheshlaghi@med.mui.ac.ir 100319475328460016617 100319475328460016617 No Department of Clinical Toxicology, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Shafeajafar Zoofaghari Shafeajafar@med.mui.ac.ir 100319475328460016618 100319475328460016618 Yes Department of Clinical Toxicology, Isfahan University of Medical Sciences, Isfahan, Iran