en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span new="" roman="" style="font-family:" times=""><b>Background: </b>Valproic acid (VPA) is a well-known antiepileptic drug; however, it has adverse effects on different body organs, particularly as a result of inducing oxidative stress in the liver. Taurine (Tau) is an amino acid prevalent in the brain that possesses anti-tumor, anti-toxic, and antioxidant properties. This study aimed to investigate the potential of the co-treatment of Tau in mitigating the deleterious effects of VPA in pentylenetetrazole (PTZ) epileptic rats. </span><br> <span new="" roman="" style="font-family:" times=""><b>Methods: </b>A total of 42 rats were divided into six groups of seven as follows: control group, PTZ-treated group (single dose, 60 mg/kg intraperitoneally [IP]), VPA-treated group (500 mg/kg IP for 14 days), Tau-treated group (100 mg/kg orally for 28 days), VPA+PTZ group, and Tau+VPA+PTZ group. The liver function, antioxidant status, and lipid profile markers were evaluated spectrophotometrically.</span><br> <span new="" roman="" style="font-family:" times=""><b>Results: </b>The IP injection of PTZ and VPA elevated aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyltransferase levels. These treatments caused negative alterations in protein concentrations, antioxidant status, and lipid profile markers of the rats&rsquo; sera. The treatment with Tau+VPA, on the other hand, improved liver function, restored fairly normal total protein and albumin levels, and improved malondialdehyde, glutathione peroxidase, and total antioxidant capacity concentrations. Furthermore, the Tau+VPA treatment significantly controlled total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein levels, compared to the VPA+PTZ treatment. </span><br> <span new="" roman="" style="font-family:" times=""><b><span style="letter-spacing:-.1pt">Conclusion: </span></b>The treatment with Tau+VPA is highly effective in controlling the unfavorable side effects of VPA in an epileptic rat model.</span></span></div> Liver function, Oxidative stress, Pentylenetetrazole, Taurine, Valproic acid 93 98 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1196-1&slc_lang=en&sid=1 Omar Hassanein omarhassanein@science.menofia.edu.eg 100319475328460016606 100319475328460016606 Yes Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Meoufia, Egypt Ibrahim A. El-Elaimy Elaimyia52@yahoo.com 100319475328460016607 100319475328460016607 No Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Meoufia, Egypt Mohamed F.F. Bayomy mffbayomy@yahoo.com 100319475328460016608 0009-0009-6919-3211 No Department of General Biology, Center of Basic Sciences, Misr University for Science and Technology, Giza, Egypt Ahmed M. Shehata ahmedmshehata@yahoo.com 100319475328460016609 100319475328460016609 No Advanced Research Unit, Egyptian Drug Authority, Cairo, Egypt Hany M. Ibrahim hany.mohamed@science.menofia.edu.eg 100319475328460016610 100319475328460016610 No Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Meoufia, Egypt