en عمومى General پژوهشي Research <span style="font-size:12px;"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB">Background: </span></b><span lang="EN-GB"><span style="letter-spacing:-.1pt">The kidneys are the main target of lead toxicity as lead is accumulated in and excreted through the kidneys. The main lead toxicity occurs through oxidative stress and lipid peroxidation, causing cellular damage in the kidneys. <i>Moringa</i> leaves contain high levels of flavonoids, with antioxidant effects that are useful in treating diseases accompanied by oxidative stress due to toxicity. Our goal was to analyze the attenuation effects of <i>Moringa</i> leaves extract on lead-induced nephrotoxicity in male Wistar rats.</span></span><span lang="EN-GB" style="font-size:1.0pt"></span></span></span><br> <span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB">Methods: </span></b><span lang="EN-GB">This research was conducted based on an experimental design and post-tests. Forty-eight <span style="letter-spacing:-.1pt">Wistar rats </span>were randomly divided into four groups as follows: control group (K), which was given lead acetate at 750 mg/kg/day for 7 days, and three other groups of P1, P2 and P3, which were given lead acetate at the same dose for 7 days followed by administering with the ethanolic extract of <i>Moringa</i> leaves at 1,000, 1,500, and 2,000 mg/kg/day doses orally for 14 days, respectively.</span><span lang="EN-GB" style="font-size:1.0pt"></span></span></span><br> <span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB">Results: </span></b><span lang="EN-GB">There were improvements in oxidative stress in the kidneys of the study rats, marked by an increase in the serum levels of GSH, GPx, CAT, and SOD, and a decrease in the kidney MDA levels. Kidney disorders can be improved by administering ethanol extract from <i>Moringa</i> leaves, which is characterized by a significant decrease in blood BUN and creatinine levels.</span><span lang="EN-GB" style="font-size:1.0pt"></span></span></span><br> <span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB"><span style="letter-spacing:-.1pt">Conclusion: </span></span></b><span lang="EN-GB">All doses of the ethanolic extract of <i>Moringa</i> leaves reduced the oxidative stress and improved the kidney function impaired due to acute exposure to lead in male Wistar rats.</span></span></span></span><span style="font-size:12pt"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" dir="RTL" style="font-size:1.0pt"></span></b></span></span></span> Lead acetate, Moringa oleifera extract, Oxidative stress, Renal function, Wistar rats 152 157 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1200-1&slc_lang=en&sid=1 Laksana Agung Saprasetya Dwi agung.laksana@unsoed.ac.id 100319475328460016700 100319475328460016700 Yes Associate Professor; Occupational and Environmental Medicine Division, Dept. of Public Health and Community Medicine, Faculty of Medicine, Universitas Jenderal Soedirman. Purwokerto, Indonesia Burkon Lily Kusumasita lily.burkon@unsoed.ac.id 100319475328460016701 0009-0000-1766-2164 No Lecturer; Occupational and Environmental Medicine Division, Dept. of Public Health and Community Medicine, Faculty of Medicine, Universitas Jenderal Soedirman. Purwokerto, Indonesia Wicaksono Madya Ardi madya.wicaksono@unsoed.ac.id 100319475328460016702 100319475328460016702 No Lecturer, Community Nutrition Division, Dept. of Public Health and Community Medicine, Faculty of Medicine, Universitas Jenderal Soedirman. Purwokerto, Indonesia Samodro Pugud pugud.samodro@unsoed.ac.id 100319475328460016703 100319475328460016703 No Assistant Professor; Internal Medicine Specialist, Dept. of Internal Medicine, Faculty of Medicine, Universitas Jenderal Soedirman. Purwokerto, Indonesia Muhammad Zaenuri Syamsu Hidayat muhammad.hidayat@unsoed.ac.id 100319475328460016704 100319475328460016704 No Forensic and Medicolegal Specialist, Dept. of Forensic and Medicolegal, Faculty of Medicine, Universitas Jenderal Soedirman. Purwokerto, Indonesia