en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="background:white"><span style="line-height:125%"><span style="unicode-bidi:embed"><span calibri=""><b><span style="line-height:125%"><span new="" roman="" times="">Background: </span></span></b><span style="line-height:125%"><span new="" roman="" times="">Aluminum is a potent inhibitor for many cation-dependent biological processes. Traditional medical practitioners for the treatment of liver disorders for centuries have used plant extracts The purpose of the study was to assess the hepatoprotective activity of hydroalcoholic extract of Cichorium intybus L. against aluminum chloride (Alcl3) intoxicated rats.<br> <b>Methods:</b> The hepatoprotective activity of extracts (hydroalcoholic extract) at 50 mg/kg body weight was compared with aluminum chloride (Alcl3)-treated animals. The animals were divided into four groups with seven animals in each group. The first group represents control, the second group received aluminum chloride, the third group received C. intybus extract, and the fourth group received C. intybus plus aluminum chloride. The duration of injection was 15 days</span></span><span new="" roman="" times="">, injection</span><span style="line-height:125%"><span new="" roman="" times=""> was done by intraperitoneal method and the sampling was done one week after the last injection.<br> <b>Results:</b> There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme in aluminum chloride intoxicated mice, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings. </span></span></span></span></span></span><br> <span style="background:white"><span style="line-height:125%"><span style="unicode-bidi:embed"><span calibri=""><b><span style="line-height:125%"><span new="" roman="" times="">Conclusion:</span></span></b><span style="line-height:125%"><span new="" roman="" times=""> The results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity.</span></span></span></span></span></span></span></span></div> Aluminum chloride, Cichorium intybus, Hepatoprotective effects, Poisoning, Enzyme 45 51 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1070-1&slc_lang=en&sid=1 Abolghasem Nabipour nabipour@um.ac.ir 100319475328460017268 100319475328460017268 Yes Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Naser Darban Maghami ndmaghamy@yahoo.com 100319475328460017269 100319475328460017269 No Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Amir Moghadam Jafari 100319475328460017270 100319475328460017270 No Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Zahra Moosavi moosavi@um.ac.ir 100319475328460017271 100319475328460017271 No Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran