en عمومى General پژوهشي Research <span style="font-size:9pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">This article presents the results of a study on the toxic effects of a copper oxide nanocomposite compound on the body of white rats over short- and long-term experiments. </span></span></span></span></span></span><br> <span style="font-size:9pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The copper oxide nanocomposite compound was orally administered daily to the rats at 500&micro;g/kg for 10 days. The examination of the effects was carried out immediately after the completion of the exposure to the nanocomposite and four months post exposure. </span></span></span></span></span></span><br> <span style="font-size:9pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Biochemical and hematological parameters in the blood, and the morphology of the brain cells in the sensorimotor cortex, and in liver and kidney cells were also investigated. </span></span></span></span></span></span><br> <span style="font-size:9pt"><span style="line-height:normal"><span style="tab-stops:369.0pt 418.5pt"><span linotype="" palatino="" style="font-family:"><span style="color:black"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The experimental findings indicated that the nanocomposite compound caused </span></span></span></span></span></span></span><br> <span style="font-size:9pt"><span style="line-height:normal"><span style="tab-stops:369.0pt 418.5pt"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">alterations in the biochemical and hematological parameters in the rats&rsquo; blood. It also affected the morphology of the rats&rsquo; brain sensorimotor cortex, without causing pronounced changes in the structure of the rats&rsquo; liver and kidneys. We also found that the copper oxide nanocomposite had a primary genotoxic effect on blood cells. In the long-term, the toxic effect of the </span></span></span></span></span></span></span><br> <span style="font-size:9pt"><span style="line-height:normal"><span style="tab-stops:369.0pt 418.5pt"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">nanocomposite compound declined.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusions:</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal"> The copper oxide nanocomposite at 500&mu;g/kg had adverse effects on the normal metabolism of the rats and was toxic to their liver and kidney cells. The cytotoxic effects of this compound were observed in the arabinogalactan matrix of the liver and kidney cells. The histological alterations were significant, which warrants further investigations when </span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal">researchers plan to use this compound in animals or humans as a drug because of its </span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:normal"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-weight:normal">antibacterial properties.</span></span></span></span></span></span></span></span><br> &nbsp; Blood, Brain, Copper oxide particles, Genotoxicity, Nanocomposite 241 249 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1237-1&slc_lang=en&sid=1 Evgeny Alekseevich Titov g57097@yandex.ru 100319475328460016875 100319475328460016875 No Senior Researcher, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia Мikhail Aleksandrovich Novikov novik-imt@mail.ru 100319475328460016876 100319475328460016876 Yes Senior Researcher, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia. Vera Aleksandrovna Vokina vokina.vera@gmail.com 100319475328460016877 100319475328460016877 No Senior Researcher, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia. Vera Aleksandrovna Tyutrina tyutrina.v.a@yandex.ru 100319475328460016878 100319475328460016878 No Officer, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia Anna Aleksandrovna Pankova nyuta.pankova.96@mail.ru 100319475328460016879 100319475328460016879 No Junior Researcher, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia. Ekaterina Vladimirovna Buynova buyncat@mail.ru 100319475328460016880 100319475328460016880 No Junior Researcher, Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia. Larisa Mikhailovna Sosedova sosedlar@mail.ru 100319475328460016881 100319475328460016881 No Professor & Head; Biomodeling and Translational Medicine Laboratory, FSBSI East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia.