en عمومى General پژوهشي Research <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">A major side effect of some cancer drugs, including Doxorubicin, is cardiotoxicity. This study was designed to evaluate the cardioprotective role of ethanolic leaf extract of <i>Gongronema latifolium</i><b> (</b>GL) compared to Lisinopril in doxorubicin-induced cardiotoxicity in rats.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Forty Wistar rats of both sexes (150-200 g) were divided into 5 groups (n=8 each). Group 1 (control) took normal rat chow; Group 2 received 25 mg/kg Doxorubicin; Group 3 received Doxorubicin + GL (200 mg/kg orally); Group 4 received Doxorubicin + Lisinopril (10 mg/kg orally); and Group 5 received Doxorubicin + Lisinopril + GL. The regiment lasted for 28 days. Blood samples were collected from each animal via cardiac puncture for biochemical assays. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The results of the study showed a significant decrease in superoxide dismutase (SOD) concentration in the doxorubicin group as compared to the control group. Intervention with GL and Lisilopril caused a significant increase in SOD concentration. Total antioxidant capacity, catalase, SOD, and angiotensin-II levels were significantly decreased with a corresponding increase in malondialdehyde (MDA) in the Doxorubicin group. Treatment with GL and Lisinopril significantly reversed these changes by increasing the levels of TAC, SOD, CAT, and angiotensin-2 to normal while lowering the MDA levels to normal. Cardiac biomarkers, namely troponin and creatine kinase levels, were significantly increased in the doxorubicin group as compared to the normal control. However, the coadministration of GL and Lisinopril decreased the troponin and creatine kinase concentrations to normal levels.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusions: </span></span></span></b><i><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Gongronema Latifolium </span></span></span></i><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">and Lisinopril provided better cardioprotective and antioxidant effects versus other agents against cardiotoxicity induced by Doxorubicin.</span></span></span></span></span></span> Antioxidants, Cardiac biomarkers, Doxorubicin, Gongronema Latifolium extract, Lisinopril 210 216 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1241-1&slc_lang=en&sid=1 Gabriel Otu Ujong Ujong4gab44@yahoo.com 100319475328460016854 100319475328460016854 Yes Physiology, Department of Physiology, Cross River State University, Okuku Campus, Cross River State, Nigeria. Justin Atiang Beshel atiangjustbesh@yahoo.com 100319475328460016855 100319475328460016855 No Department of Human Physiology, Cross River State University, Okuku Campus, Cross River State, Nigeria. Idara Asuquo Okon idyastuk@yahoo.com 100319475328460016856 100319475328460016856 No Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria. Clement Ikani Ejim ntishor84@gmail.com 100319475328460016857 100319475328460016857 No Department of Human Physiology, Cross River State University, Okuku Campus, Cross River State, Nigeria. Benedict Idam drbenidam@gmail.com 100319475328460016858 100319475328460016858 No Department of Human Physiology, Cross River State University, Okuku Campus, Cross River State, Nigeria.