en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><b>Background: </b>Cadmium-induced male infertility is associated with oxidative stress. However, there is a lack of literature regarding its effects on Cadmium-induced male reproductive toxicity, which is the motivation for conducting this study.<br> <b>Methods: </b>Twenty male Wistar rats were divided into four groups of five rats each as follows:1) Control; 2) Cadmium-only; 3) STC30-only; and 4) Cadmium+STC30. Daily administration was for 28 days, after which blood and testicular samples were collected for the determination of relevant parameters.<br> <b>Results: </b>The results demonstrated a significant loss of body weight in the Cadmium-only group compared to the control, Cadmium+STC30, and STC30-only groups. Testicular and epididymal weights were also significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Furthermore, sperm count, viability, and motility were significantly diminished in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Teratozoospermia was significantly higher in the Cadmium-only group than in the control, Cadmium+STC30, and STC30-only groups. Levels of gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, and testosterone were significantly reduced in the Cadmium-only group compared to the control group.<br> Additionally, testicular malondialdehyde and TBARS levels were significantly elevated in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Activities of superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant capacity in the testes were significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Histological analysis revealed a significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared to the control, with higher scores in the STC30-only and Cadmium+STC30 groups compared to the Cadmium-only group.<br> <b><span style="letter-spacing:-.1pt">Conclusion: </span></b>The STC30 compound ameliorated the Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.</span></span></div> STC30, Cadmium, male rats, reproductive parameters, ameliorates 26 36 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1242-1&slc_lang=en&sid=1 Justina Nwangwa uremma1@yahoo.com 100319475328460017325 100319475328460017325 No Department of Physiology, University of Calabar, Calabar, Nigeria Ekpe Aribo ekpearibo@gmail.com 100319475328460017326 0009-0001-4971-1474 Yes Department of Physiology, University of Calabar, Calabar, Nigeria Augustine Udefa augustineudefa@gmail.com 100319475328460017327 100319475328460017327 No Department of Physiology, University of Calabar, Calabar, Nigeria Atim Antai eduanwana@yahoo.com 100319475328460017328 100319475328460017328 No Department of Physiology, University of Calabar, Calabar, Nigeria