Iranian Journal of Toxicology

en The effect of Frl-ZnO and aerobic exercise on the prevention of breast cancer in a mouse model of breast cancer تخصصي Special پژوهشي Research <div style="text-align: justify;">Background: Breast cancer accounts for 23% of all neoplasias in women, which significantly impacts their physical, mental, and social aspects of life. This study investigated the effect of 8-week aerobic exercise alone or with ferulic acid administration combined with or without zinc oxide on the prevention of breast cancer in a rat model. Methods: A total of 27 rats were randomly divided into 9 groups of 3 rats each as follows: 1) Exercise only; 2) Exercise + ferulic acid; 3) Exercise + zinc; 4) Exercise + ferulic + zinc; 5) Ferulic acid only; 6 ) Zinc; 7) Ferulic + zinc; 8) Positive controls; and 9) Negative controls. In the first week, the aerobic exercise protocol consisted of a 10-minute warm-up period at a speed of 10 m/min for 20 min, which increased to a speed of 18 m/min for 30 min. The ferulic acid supplement was administered to rats intraperitoneally using insulin syringes with a volume of 200 µL. After the last training session, the rats’ breast tissue samples were excised, and the expression levels of BCL2, Bax, and caspase-3 were measured by the real-time polymerase chain reaction method. The data were analyzed by one-way ANOVA and Tukey’s post hoc test (P≥0.05). Results: The findings showed that intermittent exercise plus ferulic acid-zinc supplementation decreased the BCL2 level in the breast cancer group (P=0.004). Intermittent training supplemented with ferulic acid-zinc increased Bax and caspase-3 levels in the breast cancer group (P=0.001). Conclusion: Aerobic exercise combined with ferulic acid and zinc nanoparticles inhibited cell apoptosis promoted by breast cancer in rats.</div> Breast cancer, apoptosis, aerobic exercise, ferulic acid 182 188 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1245-1&slc_lang=en&sid=1 Maryam Pira Piramaryam@gmail.com 100319475328460016740 100319475328460016740 No PhD Student, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran Khosro Jalali Dehkordi khosrojalali@gmail.com 100319475328460016741 100319475328460016741 Yes Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran Farzaneh Taghian ft.taghian@gmail.com 100319475328460016742 100319475328460016742 No Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran Rozita Nasiri r.nasiri@gmail..com 100319475328460016743 100319475328460016743 No Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran