en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Exposure to </span></span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/ionizing-radiation" title="Learn more about Ionizing radiation from ScienceDirect's AI-generated Topic Pages"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e"><span style="text-decoration:none"><span style="text-underline:none">ionizing radiation</span></span></span></span></span></a><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">&nbsp;induces&nbsp;</span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">reactive oxygen species (ROS) which </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">leads to </span></span></span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress" title="Learn more about oxidative stress from ScienceDirect's AI-generated Topic Pages"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e"><span style="text-decoration:none"><span style="text-underline:none">oxidative stress</span></span></span></span></span></a><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">&nbsp;in the involved tissues. The oxidative stress may be minimized by using natural antioxidant products, such as </span></span></span><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Zingiber officinale </span></span></i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">or <i>ginger.</i> </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">The aim of this study was to investigate the protective and antioxidant effects of&nbsp;</span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">ginger extract on the inhibition of oxidative stress </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">in the serum and liver tissue of rats after exposure to&nbsp;</span></span></span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/skull-irradiation" title="Learn more about cranial irradiation from ScienceDirect's AI-generated Topic Pages"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e"><span style="text-decoration:none"><span style="text-underline:none">x-ray irradiation</span></span></span></span></span></a><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">: Thirty-six Sprague Dawley rats were divided into six groups. Groups 1 and 2 received normal saline and </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">DMSO, respectively</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">; </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">group 3 was placed in a turned-off X-ray device</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">; group 4 was treated with ginger extract (</span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">100 mg/kg)</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">; groups 5 and 6 received X-radiation (</span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">4 Gy)</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e"> and X-radiation + ginger extract, respectively. All treatments were orally administered once daily for four weeks. The total antioxidant capacity (TAC), total&nbsp;</span></span></span><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidizing-agent" title="Learn more about oxidant from ScienceDirect's AI-generated Topic Pages"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e"><span style="text-decoration:none"><span style="text-underline:none">oxidant</span></span></span></span></span></a><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">&nbsp;status (TOS) and </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">malondialdehyde (MDA) </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">levels were measured in the serum and liver tissues of the animals. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results<span style="color:#2e2e2e">: </span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">X-ray radiation significantly increased the levels of MDA and TOS and decreased TAC in the serum and liver tissues of irradiated rats compared to those of the control group. </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Ginger pretreatment prior to X-ray, significantly decreased the MDA and TOS levels and increased the TAC levels in the serum and liver samples of the rats compared to the rats irradiated with X-ray alone. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusions</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">: </span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">This study demonstrated that ginger acted </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2e2e2e">as a protector against X-ray radiation by suppressing the oxidative stress in the rats&rsquo; liver and serum samples.</span></span></span></span></span></span> Ginger, Liver and serum, Oxidative stress, Protection, X-ray radiation. 217 223 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1249-2&slc_lang=en&sid=1 Mohammad Hosseinzadeh hosseinzadeh.1376@yahoo.com 100319475328460016859 100319475328460016859 Yes Medical Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran Mohammad Amini mohammadamini4356@gmail.com 100319475328460016860 100319475328460016860 No Medical Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran Fatemeh Seif sahar_s59@yahoo.com 100319475328460016861 100319475328460016861 No Medical Physics, Department of Radiotherapy and Medical Physics, School of Para-Medicine, Arak University of Medical Sciences and Khansari Hospital. Arak, Iran Maryam Baazm dr.baazm@arakmu.ac.ir 100319475328460016862 100319475328460016862 No Anatomical Sciences, Department of Anatomy, School of Medicine, Arak University of Medical Sciences. Arak, Iran Ali Ganji siasiamirshayan@yahoo.com 100319475328460016863 100319475328460016863 No Department of Immunology, School of Medicine Molecular and Medicine Research Center, Arak University of Medical Sciences. Arak, Iran Amirshayan Siasi siasiamirshayan@yahoo.com 100319475328460016864 100319475328460016864 No Medical Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran Farideh Jalali-Mashayekhi siasiamirshayan@yahoo.com 100319475328460016865 100319475328460016865 No Clinical Biochemistry, Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences. Arak, Iran