Iranian Journal of Toxicology

en Effects of Taurine on Rifampin-induced Liver Injury عمومى General پژوهشي Research <div style="text-align: justify;">Background: Rifampin (RIF), which is among the first-line medications widely used to treat tuberculosis (TB), has been reported to be correlated with some side effects, including hepatotoxicity. The present study aimed to assess the hepatoprotective potential of taurine (Tau) as an antioxidant against Rifampin-induced liver damage in rats. Methods: Six groups of six male rats each (n=36) were included in the present study. Rats were treated with RIF (100 mg/kg/day) or co-treated with Rif + Tau (100, 500, or 1000 mg/kg/day) for 14 days. A single Tau treatment at a dose of 1000 mg/kg/day was administered in order to examine its hepatotoxic effects. Liver function test was used to assess Alanine transaminase (ALT), Aspartate transaminase (AST), and Lactate dehydrogenase (LDH) in blood serum samples of the examined rats. Bilirubin was estimated along with liver levels of glutathione (GSH), reactive oxygen species (ROS), total antioxidant capacity (TAC), and lipid peroxidation (LPO). Results: Treatment with RIF significantly increased ROS and LPO in the liver, as well as ALT, AST, LDH, and bilirubin in the serum. In addition, the hepatic levels of GSH and FRAP decreased in rats treated with RIF. Nonetheless, different doses of Tua significantly ameliorated the RIF-induced oxidative stress and impaired liver function.  Conclusion: As evidenced by the results of this study, Tua mitigated the liver toxicity induced by RIF via inhibiting oxidative damage to the hepatic tissue in male rats</div> Hepatotoxicity, Oxidative stress, Reactive oxygen species, Rifampin, Taurine 153 159 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1209-2&slc_lang=en&sid=1 Ali Ghaffarian-Bahraman ghafarian91@gmail.com 100319475328460018839 100319475328460018839 No Assistant Professor of Pharmacology and Toxicology, Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Salman Mohammadi s.mohammadi.diet@gmail.com 100319475328460018840 100319475328460018840 No Assistant Professor of Nutritional Sciences, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran Reza Shahmohammadloo reza.shm96@gmail.com 100319475328460018841 100319475328460018841 No Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran Salma Heidari Salmaheidari92@gmail.com 100319475328460018842 100319475328460018842 No Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Hamidreza Mohammadi hamidrezamohammadi65@yahoo.com 100319475328460018843 100319475328460018843 Yes Assistant Professor; Dept. of Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.