en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><b><span style="line-height:150%"><span new="" roman="" times="">Abstract</span></span></b><b><span dir="RTL" lang="AR-EG"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""></span></span></span></b></span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><span style="line-height:150%"><span new="" roman="" times="">One of the most prevalent metabolic conditions affecting women in their reproductive years that cause infertility or subfertility is Polycystic Ovary Syndrome, or PCOS.<strong> </strong>This was a pilot study to see whether <i>Glycyrrhiza glabra L</i>. aqueous extract (GAE) could prevent or treat PCOS in rats that had been given Estradiol^&reg;.<strong> </strong>Following acclimation, four groups of adult female Wistar albino rats weighing between 160 and 200 grams each were randomly assigned; Normal rats were used in the first group as a control, In the second group, normal rats were given 100 mg/kg of <i>Glycyrrhiza glabra</i> L orally for a period of six weeks, Third group: animals modelled by Polycystic Ovary Syndrome that were not treated served as a positive control, and lastly, <i>Glycyrrhiza glabra L</i> was administered to a group of animals modeled for PCOS for a period of six weeks. The obtained results showed that the PCOS caused by Estradiol&reg; was significantly restored by <i>Glycyrrhiza glabra L</i> extracts; The results demonstrated a considerable reduction in serum levels of FSH, LH, PRL, testosterone, E2, TNF-&alpha;, IL-1&beta;, IL-4, IL-6, and IL-10, along with a slight increase in insulin and progesterone levels, indicating that <i>Glycyrrhiza glabra L</i> extract significantly controlled PCOS deteriorations. Comparably, a noteworthy improvement in the oxidative status was noted; ovarian SOD, GPx, CAT, and GSH levels were significantly raised, accompanied by a notable decrease in MDA and NO levels. Additionally, urea, creatinine, cholesterol, triglycerides, and ALAT and ASAT activities were significantly reduced, and GAE showed nephro-hepatoprotective and anti-atherogenic capabilities; these results were in line with the comparable values of the healthy group. Histological analysis corroborated these results. In summary, GAE&#39;s phytochemicals, antioxidant, and anti-inflammatory qualities, along with its capacity to cause folliculogenesis, allowed it to effectively alleviate the effects of Estradiol^&reg;-induced polycystic ovary.</span></span></span></span></span></span></span></div> Polycystic Ovary Syndrome, Estradiol®, Glycyrrhiza glabra L, Anti-inflammatory, Antioxidant, Rat 52 61 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1122-5&slc_lang=en&sid=1 Walaa A Kandeel wlaaahmed604@yahoo.com 100319475328460017387 100319475328460017387 No PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt Seham A Farag sehamfarag @yahoo.com 100319475328460017388 100319475328460017388 No PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt Hend M Ali hendali@yahoo.com 100319475328460017389 100319475328460017389 No PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt Mahmoud Ashry mahmoud_ashry20@yahoo.com 100319475328460017390 100319475328460017390 Yes PhD in Zoology, Zoology Department, Faculty of Science, Al-Azhar University, Assuit, Egypt