Iranian Journal of Toxicology

en Initial Levels of Serum Neurogranin and Creatine Kinase as Predictors of Delayed Neuropsychiatric Sequelae of Acute Carbon Monoxide Poisoning عمومى General پژوهشي Research Background: Delayed <a href="https://www.google.com/search?sca_esv=40cf876c1461774e&sxsrf=ADLYWII6n5FSOPXyztSGWB44cYdbgdQPWg:1737461143302&q=delayed+%22neurophyschatrics%22&sa=X&ved=2ahUKEwj_rYeS44aLAxUBgv0HHbxlKs8Q5t4CegQIFxAB">neuropsychiatric</a> sequela (DNS) has been described following carbon monoxide (CO) poisoning. There is a need to identify a new prognostic marker for predicting DNS after acute CO intoxication. This study aimed to investigate the predictive value of initial levels of serum neurogranin (Ng) and creatine kinase-brain (CK-BB) and their role as predictors of DNS in patients with acute CO poisoning. Methods: This prospective cohort study was conducted on 40 patients of both genders with acute CO poisoning. All participants underwent a comprehensive history taking, clinical examination, and laboratory investigations, including the estimation of serum Ng and CK-BB levels. These cases were followed up for 3 months after acute exposure to CO for DNS signs. Results: Creatine kinase, CK-BB levels, and plasma Ng levels were significantly higher in DNS-complicated patients, compared to non-complicated ones. Patients with complicated DNS had significantly lower neurological examination, Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA) scores than those with uncomplicated DNS. Based on receiver operating characteristic analysis, COHb, CK-BB, Ng levels, and GCS had cut-off values of >20%, 18.9 U/ L, 10.42 ng/mL, and ≤14, respectively. The sensitivities were 95.65%, 91.3%, 95.65%, and 78.26%, respectively. Conclusion: Initial serum Ng and CK levels may be helpful predictors of DNS after acute CO poisoning.   Carbon monoxide poisoning, Creatine kinase, Delayed neuropsychiatric sequelae, Neurogranin, Predictors 173 181 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1363-1&slc_lang=en&sid=1 Manal Mohamed Gaber Elsawaf manal.elsawaf@med.tanta.edu.eg. 100319475328460018858 100319475328460018858 Yes Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, AL Gharbia, Tanta University, Egypt. Basem Foda basem.foda@med.tanta.edu.eg. 100319475328460018859 100319475328460018859 No Department of Neurology, Faculty of Medicine, AL Gharbia, Tanta University, Egypt. Amira Wahdan amira.wahdan@med.tanta.edu.eg. 100319475328460018860 100319475328460018860 No Professor, Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, AL Gharbia, Tanta University, Egypt. Ahmad El-Ebiary a.ebiary@med.tanta.edu.eg 100319475328460018861 100319475328460018861 No 4 Professor, Department of Clinical Toxicology, Faculty of Medicine, AL Gharbia, Tanta University, Egypt. Mona elgouhri mona.elgouhri@med.tanta.edu.eg. 100319475328460018862 100319475328460018862 No 4 Professor, Department of Clinical Toxicology, Faculty of Medicine, AL Gharbia, Tanta University, Egypt .