Iranian Journal of Toxicology

en Orlistat Administration: Cardiopulmonary Oxidative Stress and Histological Responses in Obese Rats عمومى General پژوهشي Research Background: Orlistat, while reducing dietary fat absorption for obesity, presents risks: pancreatic, hepatic, renal, and cerebellar damage. Methods: This study investigated Orlistat heart and lung toxicity, lacking in prior research. Male rats were split for five set (five each group): group 1, (C/A) was normal diet ; group 2, (C/B): Was given 30% the high fat diet; group 3, (OS-360 mg/kg); group 4, (OS-480 mg/kg); group 5, (OS-600 mg/kg). Rats were administered orally daily for 60 days. Results: The obtained results from heart tissues that orlistat induces dose-dependent oxidative stress, evidenced by increased Reactive Oxygen Species (ROS) and altered peroxiredoxin, may have deleterious effects on heart tissue and may not protect against high-fat diet-induced damage. Also in lung tissues high-dose Glutathione S-Transferase (GST) increase, biphasic ROS response, and peroxiredoxin changes with fat/low-dose Orlistat. Orlistat may have adverse effects on lung tissue, and may not protect against damage caused by a high-fat diet. Conclusion: The orlistat have adverse heart and lung effects and dose-dependent oxidative stress.   Orlistat, Anti-obesity drug, High-fat diet, Cardiopulmonary, Histology 16 28 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1413-1&slc_lang=en&sid=1 Emam Atiyah Ibadi IBADI emam.atiyah@qu.edu.iq 100319475328460018819 100319475328460018819 Yes Department of Environment, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq. Hussein Kamil Awad Awad hussein.Kamel@qu.edu.iq 100319475328460018820 0009-0002-7601-1446 No Unit of Environment and Prevention of Pollution, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq. Zainab Hudhi Farhoord Farhoord Zainabhadhi.bio@utq.edu.iq 100319475328460018821 0009-0000-7959-9738 No Department of biology, Faculty of Education for Pure Science, University of Thi-Qar, Thi-Qar, Iraq. Bilal Husam Jasim Jasim bilal.h.jasim@uotechnology.edu.iq 100319475328460018822 0009-0004-3602-1839 No Biotechnology Department, Collage of Applied Sciences, University of Technology – Iraq. Sabrean Farhan Jawad Jawad Sabrean.f.jawaad@uomus.edu.iq 100319475328460018823 100319475328460018823 No College of pharmacy Al- Mustaqbal University, 51001 Babil, Iraq.