Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1391
7
1
gregorian
2012
10
1
6
18
online
1
fulltext
en
Demographic Information and Clinical and Laboratory Findings in Acetaminophen Poisoning Cases in Rasht, Iran, in 2008
Demographic Information and Clinical and Laboratory Findings in Acetaminophen Poisoning Cases in Rasht, Iran, in 2008
تخصصي
Special
پژوهشي
Research
<b>Background:</b> Acetaminophen is widely used as an analgesic and antipyretic drug and it is a frequent cause of acute drug poisoning.This study was carried out to investigate the demographic information and clinical and laboratory findings in acetaminophen poisoning patients referred to “17 Shahrivar” and “Razi” educational hospitals, Rasht.
<br><b>Methods: </b>In this retrospective cross-sectional study, 125 patients with acetaminophen poisoning were studied. Descriptive data were analyzed by SPSS software.
<br><b>Results:</b> 90 of the patients were women and the mean age of the patients was 21.5±9.06 years. Also, 72.8% of the patients were from urban areas and most of the patients (67.2%) lived in Rasht. Spring was the most common season for the incidence of poisoning. Suicide was the most common pattern of poisoning (91.2%). The mean time interval between poisoning and use of antidote N-acetylcysteine was 4.94±3.5 hours. The most common cause of delayed administration of antidote was failure in diagnosis of poisoning. Overall, 31.2% of the patients had no significant clinical manifestations. In other patients, nausea (50.4%) was the most common clinical symptom. The most common abnormal laboratory findings were prolonged prothrombin time and international normalized ratio (29%). Liver aminotransferases were elevated only in 18% of the patients.
<br><b>Conclusion: </b>Poisoning with acetaminophen was mainly found in women, 12-20 years of age, in urban areas and spring season. Suicide was the main reason of poisoning. Regarding the most common cause of delay in antidote therapy (failure in poisoning diagnosis), establishment of a toxicology laboratory in Guilan province can help the better management of poisoned patients.
Acetaminophen, Poisoning, Rasht, Suicide.
Acetaminophen, Poisoning, Rasht, Suicide.
681
685
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-108&slc_lang=en&sid=1
Alireza
Badsar
علیرضا
بادسار
10031947532846002487
10031947532846002487
Yes
Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Guilan, Iran.
Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Guilan, Iran.
Morteza
Rahbar Taramsari
مرتضی
رهبر طارمسری
rahbar.gums@gmail.com
10031947532846002488
10031947532846002488
No
Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Guilan, Iran.
Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Guilan, Iran.
Nozar
Sotodeh Foumani
نوذر
ستوده فومنی
10031947532846002489
10031947532846002489
No
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.
Hannan
Ebrahimi
هانا
ابراهیمی
10031947532846002490
10031947532846002490
No
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.
Morteza
Fallah Karkan
مرتضی
فلاح کارکان
10031947532846002491
10031947532846002491
No
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.
Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran.