en تخصصي Special پژوهشي Research <span style="font-size:12px;"><span style="font-family:Tahoma;"><b><span style="color:#2d73b4">Background: </span></b>Myocardial infarction (MI) is a common cardiovascular disease (CVD) caused by an imbalance between the high demand for blood and the heart&#39;s ability to supply it. For the first time, the present study investigated the effects of Thymex Plus (TYM), a herbal medication containing thymol extract and honey, on platelet-related indices, red cell distribution width (RDW) to platelet counts (PLT) ratio, and hemogram changes induced by isoproterenol (ISO) in a rat model .<br> <b><span style="color:#2d73b4">Methods: </span></b>: A total of 18 male Wistar rats were divided into three groups for the study. (I) Control, with no intervention; (II) ISO + Saline, receiving ISO (85 mg/kg, s.c.) on days 1 and 2, followed by 1.5 mL normal saline (oral) on days 3&ndash;7; and (III) ISO + TYM, receiving ISO (85 mg/kg, s.c.) on days 1 and 2, followed by 1.5 mL TYM (oral) on days 3&ndash;7. After the treatment period, blood samples were collected to evaluate hemogram parameters, including hemoglobin (Hb), hematocrit (HCT), red blood cell (RBC) and reticulocyte counts, RBC indices, PLT, and RDW-to-PLT ratio (RPR).<br> <b><span style="color:#2d73b4">Results: </span></b>In the ISO group, Hb, HCT, RBC, PLT, and reticulocyte counts significantly decreased (p<0.05). The ISO-TYM group showed a non-significant increase in Hb and HCT, while PLT and mean corpuscular hemoglobin concentration (MCHC) levels increased significantly (p<0.05). The RDW percentage and RPR ratio rose considerably in the ISO group (p<0.05), and TYM treatment substantially reduced these parameters (p<0.05).<br> <b><span style="color:#2d73b4"><span style="letter-spacing:-.1pt">Conclusion: </span></span></b>The TYM demonstrated significant protective effects in hemogram indices, such as PLT, RDW, RDW to PLT ratio, and reticulocyte count on ISO-induced MI in rats. These effects included improvements. The results of the present study enhanced the potential of TYM as a compound with hematological modulating capabilities. However, to clarify the precise mechanisms of these effects, further studies are recommended.</span></span><br> &nbsp; Blood Platelets, Honey, Isoproterenol (ISO), Rats, Red Cell Distribution Width, Thymol, Wistar 1 7 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-605-2&slc_lang=en&sid=1 Sina Adib semnan.adib@gmail.com 100319475328460018808 100319475328460018808 No DVM, Veterinary Medicine, Semnan University, Semnan, Iran. Keivan Keramati K.keramati@semnan.ac.ir 100319475328460018809 100319475328460018809 Yes Department of Basic Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. Mahmood Ahmadi-hamedani Ahmadi.hamedani@semnan.ac.ir 100319475328460018810 100319475328460018810 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. Leila Mohammadnezhad Nasrabadi l.mohammadnejad.n@gmail.com 100319475328460018811 100319475328460018811 No Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.