en Effect of Aluminium Phosphide Poisoning on Blood Cortisol Level عمومى General پژوهشي Research <b>Background: </b>Acute intoxication with ALP is extremely lethal. The present study was conducted to determine the range of serum cortisol levels in ALP poisoning and its correlation with patient outcome. <br><b>Methods:</b> This study was carried out on patients who were intoxicated with ALP. Their demographic data and pertinent findings in their history and physical examination were recorded at the time of arrival and also when shock and severe metabolic acidosis emerged. 5cc blood was taken from the patients to measure blood cortisol level, when shock and severe metabolic acidosis developed. Blood cortisol level analysis was performed using ELISA method. Data analysis was done using SPSS software version 16.0. <br><b>Results: </b>The average ingested dose was 1.98+1.79 tablets each containing 3 grams of ALP. Overall, 77% of the patients presented tachycardia and hypotension. Blood cortisol level less than 15 µg/dl, 15-33 µg/dl, and more than 34 µg/dl were regarded as adrenal insufficiency, critical illness-related corticosteroid insufficiency, and adequate adrenal response, respectively. Eventually, 3 patients fell within the first category, 24 patients matched with the second category, and 3 patients corresponded to the last category. <br> <b>Conclusion</b>: Blood cortisol concentration is satisfactory only in 10% of the patients. In majority of the patients although it is not apparently low, it has not shown the expected rise comparable to the shock and stress state of such patients. It defines a role for corticosteroids therapy in management of ALP poisoning, particularly if it does not respond to conventional treatments. Adrenal Insufficiency, Aluminum Phosphide, Cortisol, Poisoning, Shock. Adrenal Insufficiency, Aluminum Phosphide, Cortisol, Poisoning, Shock. 746 750 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-29-14&slc_lang=en&sid=1 Fariba Farnaghi فریبا فرنقی 10031947532846002418 10031947532846002418 No Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Haleh Talaie هاله طالایی 10031947532846002419 10031947532846002419 No Department of Infectious Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Infectious Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zahra Pournasiri زهرا پورنصیری 10031947532846002420 10031947532846002420 No Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Roksana Sadeghi رکسانا صدقی 10031947532846002421 10031947532846002421 No Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hamid Owliaey حمید اولیایی h_owliaey@yahoo.com 10031947532846002422 10031947532846002422 Yes Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hossein Hassanian-Moghaddam حسین حسنیان مقدم 10031947532846002423 10031947532846002423 No Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shahin Shadnia شاهین شادنیا 10031947532846002424 10031947532846002424 No Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.