en Alteration in Liver Enzymes in Aluminum Phosphide Poisoning, A Retrospective Study تخصصي Special پژوهشي Research <b>Background: </b>Aluminum phosphide (ALP) or rice tablet is a common agent used as pesticides. It is cheap, widely available and highly toxic and responsible for many cases of poisoning in the agricultural communities. There is limited evidence about change of liver enzymes in patients with ALP poisoning in this region. Therefore, we decided to evaluate alteration of liver enzymes in ALP poisoning in Rasht. <b>Methods: </b>In this retrospective cross-sectional study, all documents of patients with ALP poisoning admitted to Razi hospital of Rasht in 2008-2009 were assessed. Inclusion criteria were diagnostic clinical manifestation such as hypotension or metabolic acidosis, history of exposure to ALP during the past 24 hours and progressive signs and symptoms despite treatment (administration of sodium bicarbonate and vasopressor). Patients with past history of hepatic disease were excluded. Collected data were analyzed with SPSS software. <br><b>Results: </b>Of 104 patients with ALP poisoning, 66 patients (63.5%) were men. The mean age was 33.8±14.69 years, and the mean time of hospitalization was 14.94±18.28 hours. Ninety-five patients (91.3%) needed ventilation and 93 patients (89.4%) died. Statistical analysis demonstrated that elevated liver enzymes were not significantly related with gender, age, time of admission, time of hospitalization, the need for ventilation and mortality. <br><b>Conclusion: </b>It seems that liver enzymes changes is not seen widely in ALP poisoning and had lower importance than other complications. Because of limited studies in liver enzyme alterations in these patients, it is suggested that more studies with largee sample size is performed to investigate the ALP liver side effects. Aluminum Phosphide, Poisoning, Transaminases. Aluminum Phosphide, Poisoning, Transaminases. 854 857 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-118&slc_lang=en&sid=1 Morteza Rahbar Taramsari مرتضی رهبر طارمسری 10031947532846002354 10031947532846002354 No Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Rasht, Iran. Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Rasht, Iran. Alireza Badsar علیرضا بادسار badsar@gums.ac.ir 10031947532846002355 10031947532846002355 Yes Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Rasht, Iran. Department of Forensic Medicine and Toxicology, Guilan University of Medical Sciences, Rasht, Iran. Afshin Shafaghi افشین شفقی 10031947532846002356 10031947532846002356 No Department of Gastroenterology, Guilan University of Medical Sciences, Rasht, Iran. Department of Gastroenterology, Guilan University of Medical Sciences, Rasht, Iran. Maryam Namakchian Namakin مریم مکچیان نمکین 10031947532846002357 10031947532846002357 No Medical student of Guilan University of Medical Sciences, Rasht, Iran. Medical student of Guilan University of Medical Sciences, Rasht, Iran. Hannan Ebrahimi هانا ابراهیمی 10031947532846002358 10031947532846002358 No Medical student of Guilan University of Medical Sciences, Rasht, Iran. Medical student of Guilan University of Medical Sciences, Rasht, Iran. Morteza Fallah Karkan مرتضی فلاح کارکان 10031947532846002359 10031947532846002359 No Medical student of Guilan University of Medical Sciences, Rasht, Iran. Medical student of Guilan University of Medical Sciences, Rasht, Iran.