en Methicillin Resistant Staphylococcus Aureus in Ventilator Associated ‎Pneumonia in Toxicological Intensive Care Unit تخصصي Special پژوهشي Research <b>Background: </b>Methicillin resistant Staphylococus Aureus (MRSA) is a cause of ‎nosocomial infections at intensive care unit (ICU), which imposes a high mortality and ‎morbidity on the health care systems.‎ The objective of this study was to evaluate the role of MRSA in patients with clinically ‎suspected ventilator associated pneumonia (VAP) in toxicological ICU admitted ‎patients.<b><br>Methods:</b> This cross-sectional study was performed over a period of six months from ‎August 2009 to February 2010. A total of 84 patients with clinically suspected VAP were ‎selected from all 381 ICU admitted patients under mechanical ventilation for more than ‎‎48 hours. MRSA Screen Agar was used to detect resistance in Staph aureus ‎specimens. MRSA was determined as the main outcome.‎ <br><b>Results:</b> MRSA was the cause in 54% of Staph aureus infected VAPs. Although ‎MRSA infection was not significantly associated with age, gender, cause of poisoning, ‎chronic disease, paraclinical findings, length of hospital stay, and antibiotic prescription ‎‎(P>0.05 for all comparisons), it was reported higher in those who expired than those ‎who survived (66.7% vs. 31.9%, P<0.012)‎.<br><b>Conclusion:</b> In the main referral toxicological ICU in Tehran, in more than 1 of 3 ‎clinically suspected VAP cases, MRSA was seen which was associated with the poorer ‎outcome, higher inpatient mortality.‎ Intensive Care Unit, Methicillin Resistance, Pneumonia, Staphylococus ‎Aureus, Ventilator.‎ Intensive Care Unit, Methicillin Resistance, Pneumonia, Staphylococus ‎Aureus, Ventilator.‎ 962 966 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-142&slc_lang=en&sid=1 Alireza Salimi علیرضا سلیمی 10031947532846002264 10031947532846002264 No Department of Anesthesiology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran Department of Anesthesiology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran Sepideh ‎ Kamalbeik‎ سپیده کمال بیک 10031947532846002265 10031947532846002265 No ‎ Department of Microbiology, Science and Research Branch, Islamic Azad University of Fars, Shiraz, Iran ‎ Department of Microbiology, Science and Research Branch, Islamic Azad University of Fars, Shiraz, Iran Arezou Mahdavinejad آرزو مهدوی نژاد 10031947532846002266 10031947532846002266 No Toxicological Research Center, Department of Clinical Toxicology, Loghman- Hakim Hospital, Shahid ‎Beheshti University of Medical Sciences, Tehran, Iran.‎ Toxicological Research Center, Department of Clinical Toxicology, Loghman- Hakim Hospital, Shahid ‎Beheshti University of Medical Sciences, Tehran, Iran.‎ ‎ Shahram‎ Sabeti ‎شهرام‎ ثابتی 10031947532846002267 10031947532846002267 No ‎ Loghman Hakim Hospital Laboratory, Shahid Beheshti University of Medical Sciences, Tehran, Iran.‎ ‎ Loghman Hakim Hospital Laboratory, Shahid Beheshti University of Medical Sciences, Tehran, Iran.‎ ‎ Haleh‎ Talaie ‎هاله طالایی talaie@sbmu.ac.ir 10031947532846002268 10031947532846002268 Yes Toxicological Research Center, Department of Clinical Toxicology, Loghman- Hakim Hospital, Shahid ‎Beheshti University of Medical Sciences, Tehran, Iran.‎ Toxicological Research Center, Department of Clinical Toxicology, Loghman- Hakim Hospital, Shahid ‎Beheshti University of Medical Sciences, Tehran, Iran.‎