en Application of Cold-Induced Aggregation Microextraction Based on Ionic Liquid for Determination of Trace Amount of Cadmium and Lead in Powder Milk Samples تخصصي Special پژوهشي Research <div align="left"><b>Background: </b>cold-induced aggregation micro extraction based (CIAME) based on ionic liquid was used as a rapid and simple method for determination trace amounts of cadmium and lead in milk powder by analysis with flame atomic absorption spectrometry (FAAS). <br><b>Methods: </b>Sample solution containing of Cd2+ and Pb2+ in dynamic range, phosphate buffer (pH = 9, 3 ml), diethyl dithiocarbamate (complexing agent), Triton X-100, NaPF6 ,[HMIM][PF6] (extraction solvent) were transferred into conical bottom glass tube. Sample was kept in a thermostated bath and then ice bath a cloudy solution was formed. Two phases separated by centrifugation. After removing of aqueous phase, IL-phase was dissolved in methanol and diluted was injected to the FAAS by microsampler introduction. <br><b>Results:</b> ILs, containing imidazoliumcation and hexafluoro phosphate anion, [HMIM][PF6](70mg), 200 mg NaPF6 ,0.01 mol.L-1 DDTC, 0.015% of Triton X-100 obtained, pH 9 and centrifuge time 5 min (4000 rmp) was chosen. Detection limit were obtained 0.12 µgL-1, 1.61µgL-1, RSD 0.95%, 2.2% and enrichment factor of 70, 67 for Cd and Pb, respectively. <br><b>Conclusion: </b>CIAME allows determination of cadmium and lead in real samples in a simple, rapid and safe method with only a small amount of ionic liquid was used. In comparison with the organic solvent extraction, CIAME is much safer and the determination of species in high ionic strength samples is possible. </div> Cadmium, Lead, IL, CIAME. Cadmium, CIAME, IL, Lead. 1041 1047 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-159&slc_lang=en&sid=1 Mostafa Delavar مصطفی دلاور 10031947532846003144 10031947532846003144 No Department of Pharmacology, Arak University of Medical Sciences, Arak, Iran. Department of Pharmacology, Arak University of Medical Sciences, Arak, Iran. Majid Ramezani مجید رمضانی mramazani@iau-arak.ac.ir 10031947532846003145 10031947532846003145 Yes Department of Chemistry, Arak Branch Islamic- Azad University, Arak, Iran. Department of Chemistry, Arak Branch Islamic- Azad University, Arak, Iran. Mahdi Abdollahi مهدی عبدالهی 10031947532846003146 10031947532846003146 No MSc, Expert of Control Laboratory Food and Beverage, Decorative, Hygienic Products of Arak's Medical Sciences University. MSc, Expert of Control Laboratory Food and Beverage, Decorative, Hygienic Products of Arak's Medical Sciences University. Atefeh Navabi عاطفه نوابی 10031947532846003147 10031947532846003147 No MSc, Expert of Control Laboratory Food and Beverage, Decorative, Hygienic Products of Arak's Medical Sciences University. MSc, Expert of Control Laboratory Food and Beverage, Decorative, Hygienic Products of Arak's Medical Sciences University. Abdolreza Baderestani عبدالرضا بادرستانی 10031947532846003148 10031947532846003148 No MSc, Expert of Control Office on Food and Beverage, Decorative, Hygienic Products of Arak’s Medical Sciences University. MSc, Expert of Control Office on Food and Beverage, Decorative, Hygienic Products of Arak’s Medical Sciences University. Shoukofeh Hadavand شکوفه هداوند 10031947532846003149 10031947532846003149 No MSc, Chemistry Expert Advisor, Arak University of Medical Sciences, Arak, Iran. MSc, Chemistry Expert Advisor, Arak University of Medical Sciences, Arak, Iran. Masoodeh Sadeghi مسعوده صادقی 10031947532846003150 10031947532846003150 No MSc, Chemistry Expert Advisor, Arak University of Medical Sciences, Arak, Iran. MSc, Chemistry Expert Advisor, Arak University of Medical Sciences, Arak, Iran.