en Protective Role of Royal Jelly in Oxymetholone-induced Oxidative Injury in Mouse Testis تخصصي Special پژوهشي Research <div align="left"><b>Background: </b>An adverse effect of oxymetholone (OXM), an anabolic-androgenic steroid used as energetic medicine, is reproductive toxicity. Royal jelly (RJ) is an efficient antioxidant that has been used to treat reproductive problems. In this study, we investigated the effects of RJ on OXM-induced oxidative injuries in mouse testes. <br><b>Methods: </b>Male mice were divided into four groups. Two groups of mice were administered OXM (5 mg/kg/day, p.o.) for 28 days. One of these groups received RJ (100 mg/kg/day, p.o.) concurrently. A vehicle-treated control group and a RJ control group were also included. <br><b>Results: </b>The OXM-treated group showed a significant decrease in the serum testosterone concentration and spermatogenic activities, along with many histological alterations. OXM treatment also caused a significant decrease in catalase activity with an increase in lipid peroxidation in the mouse testes. The above-noted parameters were restored to near normal levels by RJ co-administration. <br><b>Conclusion: </b>The results demonstrate that RJ protects against OXM-induced reproductive toxicities. </div> Mouse, Oxymetholone, Royal Jelly, Testis. Mouse, Oxymetholone, Royal Jelly, Testis. 1073 1080 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-162&slc_lang=en&sid=1 Gholamreza Najafi غلامرضا نجفی 10031947532846003078 10031947532846003078 No Department of Basic Sciences, Urmia University, Urmia, Iran. Department of Basic Sciences, Urmia University, Urmia, Iran. Vahid Nejati وحید نجاتی 10031947532846003079 10031947532846003079 No Department of Biology, Urmia University, Urmia, Iran. Department of Biology, Urmia University, Urmia, Iran. Ali Shalizar Jalali علی شالیزار جلالی a.shalizar@urmia.ac.ir 10031947532846003080 10031947532846003080 Yes Department of Basic Sciences, Urmia University, Urmia, Iran. Department of Basic Sciences, Urmia University, Urmia, Iran. Ensieh Zahmatkesh انسیه زحمتکش 10031947532846003081 10031947532846003081 No Department of Biology, Urmia University, Urmia, Iran. Department of Biology, Urmia University, Urmia, Iran.