en Management of 2, 4- Dichlorophenoxyacetic Acid Intoxication by Hemodialysis: A Case Report تخصصي Special گزارش مورد case report <p dir="ltr"><strong>Background:</strong> The herbicide 2, 4-dichlorophenoxyacetic acid (2, 4-D) can cause moderate to lethal poisoning. Although urine alkalization has been recommended as the main treatment, hemodialysis (HD) may be more effective in severe cases.</p> <p dir="ltr"><strong>Case:</strong> On 24^th June 2014, a 53- year-old man ingested a high amount of 40% 2, 4-D. He suffered from mouth and epigastric burning sensation, vomiting and nausea. He was treated, in Emam Reza&rsquo;s Hospital of Mashhad University Of Medical Sciences, Mashhad , Iran,&nbsp; with maintenance daily fluid infusion plus 10 meq/L NaHCO3. Up to 9 hours after exposure, he became progressively stuporous. He developed diarrhea and hypotension, BP=100/60, unresponsive to volume replacement therapy. He received regular hemodialysis (HD) with bicarbonate for three hours. At the end of HD, his blood pressure rose to 110/70 and the level of consciousness began to improve. Four hours later, he was fully conscious with stable blood pressure (130/80 mmHg).</p> <p dir="ltr"><strong>Conclusion:</strong> HD may be an effective, safe and fast method for 2, 4-D high dose intoxication induced coma.</p> 2, 4- dichlorophenoxyacetic acid, Alkaline diuresis, Hemodialysis, Herbicide intoxication, Iran. 53 55 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-303-1&slc_lang=en&sid=1 Mohammad Moshiri محمد مشیری 100319475328460011132 100319475328460011132 No Department of Pharmacodynamic and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacodynamic and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran. Seyed Reza Mousavi سید رضا موسوی 100319475328460011133 100319475328460011133 No Department of Clinical Toxicology and Medical Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Clinical Toxicology and Medical Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran. Leila Etemad لیلا اعتماد etemadl@mums.ac.ir 100319475328460011134 100319475328460011134 Yes PhD.of Toxicology, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. PhD.of Toxicology, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.