en Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose تخصصي Special پژوهشي Research <p dir="ltr"><strong>Background: </strong>Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone.</p> <p dir="ltr"><strong>Methods: </strong>In this single-blind clinical trial, 80 patients with methadone overdose syndrome were randomly divided into two equal groups. The patients in infusion group received a constant infusion of naloxone preparation while in the patients in PRN group, naloxone was administered only if needed clinically. Severity of withdrawal syndrome was evaluated after 30 min, 3 h, and 12 h of the treatments in both groups.</p> <p dir="ltr"><strong>Results: </strong>Eighty patients completed the study (10 women and 70 men). Both groups were similar in terms of mean age, sex ratio, and the severity of intoxication. The severity of withdrawal symptom was significantly lower in the PRN group (P<0.001).</p> <p dir="ltr"><strong>Conclusion: </strong>Naloxone administration as PRN mode lowers the rate and severity of withdrawal syndrome. It is recommended as the preferred mode of naloxone administration.</p> Infusion, Methadone Intoxication, Naloxone, PRN, Withdrawal syndrome. 49 52 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-330-1&slc_lang=en&sid=1 Arash Yazdanbakhsh آرش یزدان بخش 100319475328460011135 100319475328460011135 No Department of Emergency Medicine, Arak University of Medical Science, Arak, Iran. Department of Emergency Medicine, Arak University of Medical Science, Arak, Iran. Amir Mohammad Kazemifar محمد کاظمی فر 100319475328460011136 100319475328460011136 No Department of Toxicology, Qazvin University of Medical Science, Qazvin, Iran. Department of Toxicology, Qazvin University of Medical Science, Qazvin, Iran. Kamyar Nazari کامیار نظری 100319475328460011137 100319475328460011137 No MD, Arak University of Medical Science, Arak, Iran. MD, Arak University of Medical Science, Arak, Iran. Bahman Sadeghi Sedeh بهمن صادقی dr.sadeghis@arakmu.ac.ir 100319475328460011138 100319475328460011138 Yes Department of Social Medicine, Arak University of Medical Science, Arak, Iran. Department of Social Medicine, Arak University of Medical Science, Arak, Iran. Hassan Solhi حسن صلحی 100319475328460011139 100319475328460011139 No Department of Toxicology, Arak University of Medical Science, Arak, Iran. Department of Toxicology, Arak University of Medical Science, Arak, Iran.